Glaucoma risk may be lower with higher folate intake

May 15, 2014
Glaucoma risk may be lower with higher folate intake

(HealthDay)—The risk of exfoliation glaucoma (EG)/secondary glaucoma (SEG) may be lowered with higher total folate intake, according to a study published in the May issue of JAMA Ophthalmology.

Jae H. Kang, Sc.D., from Brigham & Women's Hospital in Boston, and colleagues analyzed data from a subset of 78,980 women participating in the Nurses' Health Study and 41,221 men participating in the Health Professionals Follow-up Study. Participants were 40 years or older, free of , had completed diet questionnaires, and reported eye examinations.

The researchers found that, in pooled analyses, vitamin B6 and vitamin B12 intake was not associated with EG/SEG risk (P = 0.52 and 0.99, respectively). A trend of reduced risk was detected with higher folate intake, with a relative risk for EG/SEG for the highest folate quintile (≥654 µg/d) of 0.75 (95 percent confidence interval, 0.54 to 1.04; P = 0.02), compared to the lowest quintile. For supplemental folate intake, an association was seen, but no association was seen for dietary folate only (P = 0.003 and 0.64, respectively). There was a modest suggestive inverse association observed for greater frequency of multivitamin use (current multivitamin use of at least six times per week versus nonuse multivariable relative risk, 0.84; 95 percent confidence interval, 0.64 to 1.11; P = 0.06).

"Higher total folate intake was associated with a suggestive lower risk for EG/SEG, supporting a possible causal role of homocysteine in EG/SEG," the authors write.

Explore further: Higher total folate intake may be associated with lower risk of exfoliation glaucoma

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Higher total folate intake may be associated with lower risk of exfoliation glaucoma

April 3, 2014
Exfoliation glaucoma (EG), caused by exfoliation syndrome, a condition in which white clumps of fibrillar material form in the eye, is the most common cause of secondary open-angle glaucoma and a leading cause of blindness ...

Moderate alcohol intake linked to reduced risk of RA

May 6, 2014
(HealthDay)—There is a modest association between long-term, moderate alcohol consumption and reduced risk of rheumatoid arthritis (RA) in women, according to a study published online April 11 in Arthritis & Rheumatology.

High folate intake may reduce risk of colorectal cancer

July 5, 2011
Intake of high levels of folate may reduce colorectal cancer risk, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Folate is a water-soluble ...

Long-term dietary fiber intake linked to Crohn's disease

December 2, 2013
(HealthDay)—Long-term intake of dietary fiber is associated with a reduced risk of Crohn's disease (CD), but not ulcerative colitis (UC), according to a study published in the November issue of Gastroenterology.

New study links caffeinated coffee to vision loss

October 4, 2012
A new study suggests caffeinated coffee drinkers should limit their intake to reduce their chances of developing vision loss or blindness. According to a scientific paper in Investigative Ophthalmology & Visual Science, heavy ...

Recommended for you

Study advances gene therapy for glaucoma

January 16, 2018
While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains ...

New study offers added hope for patients awaiting corneal transplants

January 9, 2018
New national research led by Jonathan Lass of Case Western Reserve University School of Medicine has found that corneal donor tissue can be safely stored for 11 days before transplantation surgery to correct eye problems ...

Diabetic blindness caused and reversed "trapped" immune cells in rodent retinas

January 3, 2018
Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels ...

Ophthalmologists increasingly dissatisfied with electronic health records

December 29, 2017
Ophthalmologists' use of electronic health records (EHR) systems for storing and accessing patients' medical histories more than doubled between 2006 and 2016, while their perceptions of financial and clinical productivity ...

Higher omega-3 fatty acid intake tied to lower glaucoma risk

December 26, 2017
(HealthDay)—Increased daily intake of ω-3 fatty acids is associated with lower odds of glaucoma, but higher levels of total polyunsaturated fatty acid (PUFA) intake are associated with higher odds of developing glaucoma, ...

Protein analysis allows for treatment of eye-disease symptoms with existing drugs

December 21, 2017
Demonstrating the potential of precision health, a team led by a researcher at the Stanford University School of Medicine has matched existing drugs to errant proteins expressed by patients with a rare eye disease.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.