Added corticosteroid deemed ineffective for cancer pain

July 16, 2014
Added corticosteroid deemed ineffective for cancer pain

(HealthDay)—The addition of methylprednisolone (MP) to opioid therapy does not appear to increase the analgesic effect for cancer pain, according to research published online July 7 in the Journal of Clinical Oncology.

Ørnulf Paulsen, M.D., of the Telemark Hospital Trust in Skien, Norway, and colleagues randomly assigned 50 adult patients receiving opioids for cancer pain to either with MP or placebo (PL).

At day seven, the researchers observed no difference between the groups in pain intensity (MP, 3.60 versus PL, 3.68; P = 0.88) or relative analgesic consumption (MP, 1.19 versus PL, 1.20; P = 0.95). Patients receiving MP, compared with those receiving PL, experienced reduced fatigue (−17 versus 3 points; P = 0.003), decreased appetite loss (−24 versus 2 points; P = 0.003), and increased (5.4 versus 2.0 points; P = 0.001). No differences in adverse effects were observed between the groups.

"MP 32 mg daily did not provide additional analgesia in patients with cancer receiving opioids, but it improved fatigue, appetite loss, and patient satisfaction," the authors write. "Clinical benefit beyond a short-term effect must be examined in a future study."

Explore further: Chiropractic care beats sham therapy for spinal pain

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Chiropractic care beats sham therapy for spinal pain

November 19, 2013
(HealthDay)—Short-term chiropractic therapy is more effective than a sham intervention for treating spinal pain, but the difference is not clinically meaningful, according to research published in the Nov. 15 issue of Spine.

Drinking coffee, smoking may protect against cholangitis

July 8, 2014
(HealthDay)—Coffee consumption and smoking might protect against the development of primary sclerosing cholangitis (PSC), according to a study published in the June issue of Clinical Gastroenterology and Hepatology.

Screening tool does not cut distress in cancer patients

September 7, 2013
(HealthDay)—Distress monitoring and needs assessment using the Distress Thermometer and Problem List (DT&PL) does not appear to be cost-effective in improving mood states in cancer patients, according to research published ...

Beta-blockers have no impact on cocaine-related chest pain

June 3, 2014
(HealthDay)—For patients with cocaine-associated chest pain, there are no differences in outcome for those treated with or without β-blockers, according to a study published in the June 1 issue of The American Journal ...

Multimodal analgesia lessens post-op morphine needs

August 23, 2013
(HealthDay)—A multimodal analgesia combination appears to be safe and effective for pain relief after lumbar decompressive laminectomy, according to a study published in the August issue of the Journal of Spinal Disorders ...

Evidence lacking for long-term opioid use in low back pain

April 16, 2014
(HealthDay)—There is evidence of short-term efficacy (moderate for pain and small for function) of opioids for treatment of chronic low back pain (CLBP) compared with placebo; however, the effectiveness and safety of long-term ...

Recommended for you

New approach attacks 'undruggable' cancers from the outside in

January 23, 2018
Cancer researchers have made great strides in developing targeted therapies that treat the specific genetic mutations underlying a patient's cancer. However, many of the most common cancer-causing genes are so central to ...

Study: Cells of three advanced cancers die with drug-like compounds that reverse chemo failure

January 23, 2018
Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers—ovarian, prostate and breast.

'Hijacker' drives cancer in some patients with high-risk neuroblastoma

January 23, 2018
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. The resulting insights ...

Enzyme inhibitor combined with chemotherapy delays glioblastoma growth

January 23, 2018
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.