Type of lymphoma treatment impacts degree of harm to sperm

July 28, 2014
Type of lymphoma treatment impacts degree of harm to sperm
Lymphoma treatment has damaging effects on spermatogenesis but, in most patients, sperm production recovers within two years post-treatment, according to a study published online July 17 in Fertility and Sterility.

(HealthDay)—Lymphoma treatment has damaging effects on spermatogenesis but, in most patients, sperm production recovers within two years post-treatment, according to a study published online July 17 in Fertility and Sterility.

Louis Bujan, M.D., Ph.D., from Université de Toulouse in France, and colleagues compared sperm characteristics in 75 Hodgkin's lymphoma and non-Hodgkin's (before treatment and after three, six, 12, and 24 months) and a of 257 fertile men.

The researchers found that patients with no identified risk factor already had altered sperm characteristics before . After treatment, , total sperm count, motility, and vitality decreased, with lowest seen values at three and six months. Mean sperm count recovered to pretreatment values after doxorubicin, bleomycin, vinblastine, darcarbacine (ABVD) or ABVD + radiotherapy at 12 months after treatment, but not after doxorubicin, cyclophosphamide, vincristine, prednisone or mechlorethamine, oncovin, procarbazine, prednisone chemotherapies. At 24 months, 7 percent of patients remained azoospermic. Only pretreatment total sperm count was related to recovery in multivariate analyses, including diagnosis and treatment protocol.

"Lymphoma patients had altered sperm DNA and chromatin before treatment. Lymphoma treatment had damaging effects on spermatogenesis," the authors write. "These data on both the recovery period according to treatment modalities and the pre- and post-treatment chromatin status of sperm are useful tools for counseling patients wishing to conceive."

Explore further: Frozen testicle tissue yields healthy baby mice

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Frozen testicle tissue yields healthy baby mice

July 1, 2014
Sperm grown from the frozen testicle tissue of newborn mice has been used to produce healthy offspring, in a hopeful development for men left infertile by childhood cancer treatment, researchers said Tuesday.

Increased risk of relapse omitting RT in early PET scan negative Hodgkin lymphoma

March 19, 2014
Interim analysis of the intergroup EORTC-LYSA-FIL 20051 H10 trial published in the Journal of Clinical Oncology indicates an increased risk of early relapse when omitting radiotherapy in early PET scan negative patients with ...

The outcome of fertility treatments using donor sperm is dependent on the quality of sperm

June 30, 2014
Despite emerging evidence of a decline in sperm quality with increasing age, an analysis of every first fertility treatment cycle performed in the UK using sperm donation shows that outcome in terms of live birth is not affected ...

HIV status doesn't influence Hodgkin's lymphoma outcome

October 11, 2012
(HealthDay)—Despite more extensive disease and more adverse prognostic factors, HIV-positive patients with Hodgkin's lymphoma (HL) do not have worse outcomes when treated with doxorubicin, bleomycin, vinblastine, and dacarbazine ...

Mitochondrial respiratory capacity, sperm motility linked

April 10, 2012
(HealthDay) -- Sperm with higher motility have increased mitochondrial respiratory capacity, according to a study published in the April issue of Urology.

Recommended for you

Cancer-death button gets jammed by gut bacterium

July 27, 2017
Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy ...

Researchers release first draft of a genome-wide cancer 'dependency map'

July 27, 2017
In one of the largest efforts to build a comprehensive catalog of genetic vulnerabilities in cancer, researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have identified more than 760 genes ...

Long-sought mechanism of metastasis is discovered in pancreatic cancer

July 27, 2017
Cells, just like people, have memories. They retain molecular markers that at the beginning of their existence helped guide their development. Cells that become cancerous may be making use of these early memories to power ...

Blocking the back-door that cancer cells use to escape death by radiotherapy

July 27, 2017
A natural healing mechanism of the body may be reducing the efficiency of radiotherapy in breast cancer patients, according to a new study.

Manmade peptides reduce breast cancer's spread

July 27, 2017
Manmade peptides that directly disrupt the inner workings of a gene known to support cancer's spread significantly reduce metastasis in a mouse model of breast cancer, scientists say.

Glowing tumor technology helps surgeons remove hidden cancer cells

July 27, 2017
Surgeons were able to identify and remove a greater number of cancerous nodules from lung cancer patients when combining intraoperative molecular imaging (IMI) - through the use of a contrast agent that makes tumor cells ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.