New genetic test may change how brain cancer is treated, researchers say

August 20, 2014 by Tiffany L Trent, Virginia Tech

(Medical Xpress)—Scientists at Virginia Tech's Virginia Bioinformatics Institute working with the Center for Cancer and Blood Disorders at Children's National Medical Center have found a new way to diagnose brain cancer based on genetic markers found in "junk DNA."

The finding, recently published in Oncotarget, could revolutionize the way doctors treat certain cancers.

Brain cancer is the second leading cancer-related cause of death in children. Overall, 70,000 new patients were diagnosed with primary in 2013, according to the American Brain Tumor Association.

However, only about a third turn out to be malignant. Ordinarily, when a patient shows symptoms of a brain tumor, an MRI is performed to locate tumors, but it cannot determine whether the tumor is benign or malignant, often necessitating costly and occasionally dangerous or inconclusive biopsies.

A simple blood test to detect could change all that.

"Patients with less aggressive types of cancer as determined by this test would not need a biopsy," said Harold 'Skip' Garner, a professor and director of the Medical Informatics and Systems Division at the Virginia Bioinformatics Institute. "The biopsy is expensive both medically and financially—one percent of patients die and seven percent have permanent neurological damage from the procedure, according to the Canadian Journal of Neurology. This finding may reduce costs and save lives."

Microsatellites, long dismissed as "junk DNA," comprise the one million DNA sequence repeats in the human genome.

Though they've been effective in identifying rare conditions such as Huntington's and Fragile X syndrome, next-generation genome sequencing is allowing researchers to find increasingly more markers for a variety of diseases, including and autism.

The study analyzed germline (blood) sequences from the National Institutes of Health 1000 Genomes Project and the Cancer Genome Atlas.

Analyzing the microsatellites from these sequences revealed that patients with various stages of glioma showed recognizable and consistent markers in their genomes for the disease.

This information indicates it is possible to develop a simple blood test that would help identify patients with different grades, which could reduce invasive and inconclusive brain biopsies.

These new, microsatellite-based diagnostics are applicable to many other cancers and diseases. It is hoped that with continued study, more markers and potential drug targets or therapies will be found.

To further the development of such diagnostics, Garner has founded Genomeon, which holds an exclusive license in microsatellite technologies worldwide. Michael B. Waitzkin, CEO of Genomeon, said, "A that can reliably differentiate between a malignant and benign brain tumor will have important clinical significance potentially preventing unnecessary brain biopsies which carry great risks to the patient and substantial costs to the health care system."

Explore further: Researchers discover new markers for breast cancer that may aid diagnoses, point to new therapies

More information: Karunasena, E., McIver, L., Rood, B., Wu, X., Zhu, H., Bavarva, J., & Garner, H. (2014). Somatic intronic microsatellite loci differentiate glioblastoma from lower-grade gliomas. Oncotarget, 5(14), 6003-6014. Retrieved from www.impactjournals.com/oncotar … view&path%5B%5D=2076

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