Photodynamic therapy vs. cryotherapy for actinic keratoses

August 27, 2014, The JAMA Network Journals

Photodynamic therapy (PDT, which uses topical agents and light to kill tissue) appears to better clear actinic keratoses (AKs, a common skin lesion caused by sun damage) at three months after treatment than cryotherapy (which uses liquid nitrogen to freeze lesions).

AKs are rough, scaly on the skin typically found on individuals with fair complexions who have had lots of sun exposure. The lesions have the potential to become cancer. PDT is an increasingly popular treatment.

The authors compared PDT with cryotherapy in a meta-analysis of four studies that included 641 patients with a total of 2,174 AKs treated with cryotherapy and 2,170 lesions treated with PDT.

Patients treated with PDT had a 14 percent better chance of complete lesion clearance at three months after treatment than cryotherapy for thin AKs on the face and scalp.

"An analysis of the effectiveness of PDT compared with other treatments may help physicians decide what role it should play in their own clinical practice." Gayatri Patel, M.D., M.P.H., of the University of California Davis Medical Center, in Sacramento, and colleagues said in their JAMA Dermatology article.

In a related editorial, Harvey Lui, M.D., F.R.C.P.C., of the University of British Columbia, writes: "Notwithstanding the apparent superiority of PDT to cryotherapy, the light-based approach to treating AK has three major limitations. The current financial remuneration model is a major disincentive. … Although PDT appears to be a simple concept, in practice optimal results may require longer drug incubation times and perhaps light-dose fractionation to generate a sufficient tissue effect. … Finally, local pain owing to photosensitizer activation during light exposure is perhaps the most striking adverse effect that clinicians need to anticipate and manage during PDT."

"All three of these limiting factors necessitate added time and resources compared with the relatively brief outpatient visits for , in which is simply and efficiently dispensed to the skin," Lui notes.

Explore further: Common therapies for basal cell carcinoma offer similar survival

More information: JAMA Dermatology. Published online August 27, 2014. DOI: 10.1001/jamadermatol.2014.1253
JAMA Dermatology. Published online August 27, 2014. DOI: 10.1001/jamadermatol.2014.1869

Related Stories

Common therapies for basal cell carcinoma offer similar survival

May 25, 2012
(HealthDay) -- For patients with superficial basal cell carcinoma (sBCC), treatment with imiquimod or photodynamic therapy (PDT) results in similar long-term tumor-free survival, according to a review published online May ...

An easier, safer, and more accurate treatment for pancreatic cancer

April 2, 2014
Using CT scans with contrast enhancement, Dartmouth researchers measured treatment response to pancreatic cancer photodynamic therapy (PDT) according to a paper published in Physics in Medicine and Biology.

Biochips for better cancer therapy

February 25, 2014
Cancer is the second leading cause of disease-related death in the United States, and may overtake heart disease without aggressive new therapies. One promising area of cancer treatment is photodynamic therapy (PDT), which ...

Multimodal palliative approach OK for advanced esophageal CA

February 27, 2012
(HealthDay) -- For patients with advanced esophageal cancer, use of an individualized, multimodal approach with palliative intention achieves an acceptable mean survival time, with initial use of photodynamic therapy (PDT) ...

Light dynamics for cancer treatment

May 3, 2012
Research is delving into refinement of a revolutionary cancer treatment, photodynamic therapy (PDT). Using light, reactive oxygen and photosensitisers linked to specially designed antibodies, scientists are on the threshold ...

Recommended for you

Scientists make significant discovery in the fight against drug-resistant tuberculosis

September 20, 2018
A team of scientists have identified a naturally occurring antibiotic that may help in the fight against drug-resistant Tuberculosis.

Anti-cancer drugs may hold key to overcoming antimalarial drug resistance

September 20, 2018
Scientists have found a way to boost the efficacy of the world's most powerful antimalarial drug with the help of chemotherapy medicines, according to new research published in the journal Nature Communications.

Affordable Care Act: Study finds surprising gaps in HIV care providers' knowledge

September 20, 2018
A new study has revealed surprising gaps in some HIV medical providers' knowledge of the Affordable Care Act, with more than a quarter of providers surveyed unable to say whether their state had expanded Medicaid.

Preventing a dengue outbreak at the 2020 Summer Olympics

September 20, 2018
In 2014, a dengue outbreak unexpectedly occurred in Tokyo. What does that mean for the 2020 summer Olympics and Paralympics being held in the city? Researchers report this week in PLOS Neglected Tropical Diseases that new ...

Researchers discover influenza virus doesn't replicate equally in all cells

September 19, 2018
The seasonal flu is caused by different subtypes of Influenza A virus and typically leads to the death of half a million people each year. In order to better understand this virus and how it spreads, University of Minnesota ...

Flu season forecasts could be more accurate with access to health care companies' data

September 19, 2018
In an era when for-profit companies collect a wealth of data about us, new research from The University of Texas at Austin shows that data collected by health care companies could—if made available to researchers and public ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.