Scientists confirm effectiveness of cognitive rehabilitation in multiple sclerosis

August 8, 2014, Kessler Foundation

Kessler Foundation researchers published long-term followup results of their MEMREHAB trial, which show that in individuals with MS, patterns of brain activity associated with learning were maintained at 6 months post training. The article, A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial, was published online ahead of print on June 14 by Brain Imaging and Behavior. The article appeared in the Neuroimaging and Rehabilitation Special Issue. The authors are Ekaterina Dobryakova, PhD, Glenn Wylie, DPhil, John DeLuca, PhD, and Nancy Chiaravalloti, PhD, of Kessler Foundation.

This pilot study was based on the Foundation's MEMREHAB Trial, which provided the first Class I evidence for the efficacy of cognitive rehabilitation in MS. (Chiaravalloti N, et al: An RCT to treat in MS. Neurology 2013(81) doi: 10.1212/01.wnl.0000437295.97946.a8S), was released as an epub ahead of print on November 8. The 10-session memory retraining protocol used in the MEMREHAB study was the modified Story Memory Technique (mSMT).

For the , participants underwent evaluation of memory performance and at baseline, immediately following memory retraining, and at 6-month followup. Results showed that the patterns of increased cerebral activation that correlated with learning were maintained at 6-month followup. "These results support the long-term effectiveness of in individuals with cognitive impairment caused by MS," said Nancy Chiaravalloti, PhD, director of Neuroscience & Neuropsychology and Traumatic Brain Injury (TBI) Research at Kessler Foundation."For optimal care, it is crucial for clinicians who care for this population to become familiar with the mSMT protocol."

The mSMT protocol has been translated into Spanish and is being used in the U.S., Mexico, and Argentina. A Chinese translation has also been completed for use in upcoming studies. The protocol is currently being tested in the population with caused by TBI.

Explore further: Study provides first Class 1 evidence for cognitive rehabilitation in MS

More information: DOI: 10.1007/s11682-014-9309-9

Related Stories

Study provides first Class 1 evidence for cognitive rehabilitation in MS

November 21, 2013
Kessler Foundation researchers published the results of the MEMREHAB Trial in Neurology, the medical journal of the American Academy of Neurology, providing the first Class I evidence for the efficacy of cognitive rehabilitation ...

Study reports greater brain activation after cognitive rehabilitation for MS

January 17, 2012
Neuroscientists at Kessler Foundation have documented increased cerebral activation in patients with multiple sclerosis (MS) following memory retraining using the modified Story Memory Technique (mSMT).

MS researchers find task meaningfulness influences learning and memory

February 21, 2014
Kessler Foundation researchers have found that among persons with multiple sclerosis, self-generation may be influenced by variables such as task meaningfulness during learning and memory. They also found that type of task ...

Researchers publish one of the longest longitudinal studies of cognition in multiple sclerosis

June 24, 2014
Researchers at Kessler Foundation and the Cleveland Clinic have published one of the longest longitudinal studies of cognition in multiple sclerosis (MS). The article, "Cognitive impairment in multiple sclerosis: An 18-year ...

Dr. Chiaravalloti comments on trends in rehabilitation research in MS

September 14, 2012
Nancy Chiaravalloti, PhD, an expert in cognitive rehabilitation research, authored two commentaries on trends in multiple sclerosis (MS) research. Dr. Chiaravalloti is director of Neuropsychology & Neuroscience Research at ...

Researchers identify impaired new learning in persons with Parkinson's disease

March 19, 2014
Kessler Foundation scientists collaborated with colleagues in Spain to study memory and learning in patients with Parkinson Disease (PD). They found that the Parkinson group's ability to learn new information was significantly ...

Recommended for you

When the eyes move, the eardrums move, too

January 23, 2018
Simply moving the eyes triggers the eardrums to move too, says a new study by Duke University neuroscientists.

Cognitive training helps regain a younger-working brain

January 23, 2018
Relentless cognitive decline as we age is worrisome, and it is widely thought to be an unavoidable negative aspect of normal aging. Researchers at the Center for BrainHealth at The University of Texas at Dallas, however, ...

Lifting the veil on 'valence,' brain study reveals roots of desire, dislike

January 23, 2018
The amygdala is a tiny hub of emotions where in 2016 a team led by MIT neuroscientist Kay Tye found specific populations of neurons that assign good or bad feelings, or "valence," to experience. Learning to associate pleasure ...

Your brain responses to music reveal if you're a musician or not

January 23, 2018
How your brain responds to music listening can reveal whether you have received musical training, according to new Nordic research conducted in Finland (University of Jyväskylä and AMI Center) and Denmark (Aarhus University).

New neuron-like cells allow investigation into synthesis of vital cellular components

January 22, 2018
Neuron-like cells created from a readily available cell line have allowed researchers to investigate how the human brain makes a metabolic building block essential for the survival of all living organisms. A team led by researchers ...

Finding unravels nature of cognitive inflexibility in fragile X syndrome

January 22, 2018
Mice with the genetic defect that causes fragile X syndrome (FXS) learn and remember normally, but show an inability to learn new information that contradicts what they initially learned, shows a new study by a team of neuroscientists. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.