Ingredient in olive oil kills cancer cells with their own enzymes

February 16, 2015 by Ken Branson, Rutgers University
Ingredient in olive oil kills cancer cells with their own enzymes
Extra-virgin olive oil contains an ingredient, oleocanthal, that kills cancer cells without harming healthy cells, researchers have found.

A Rutgers nutritional scientist and two cancer biologists at New York City's Hunter College have found that an ingredient in extra-virgin olive oil kills a variety of human cancer cells without harming healthy cells.
The ingredient is oleocanthal, a compound that ruptures a part of the cancerous cell, releasing enzymes that cause cell death.

Paul Breslin, professor of nutritional sciences in the School of Environmental and Biological Sciences, and David Foster and Onica LeGendre of Hunter College, report that oleocanthal kills cancerous cells in the laboratory by rupturing vesicles that store the cell's waste. LeGendre, the first author, Foster, the senior author, and Breslin have published their findings in Molecular and Cellular Oncology.

According to the World Health Organization's World Cancer Report 2014, there were more than 14 million new cases of cancer in 2012 and more than 8 million deaths.

Scientists knew that oleocanthal killed some cancer cells, but no one really understood how this occurred. Breslin believed that oleocanthal might be targeting a key protein in cancer cells that triggers a programmed , known as apoptosis, and worked with Foster and Legendre to test his hypothesis after meeting David Foster at a seminar he gave at Rutgers.

"We needed to determine if oleocanthal was targeting that protein and causing the cells to die," Breslin said.  

After applying oleocanthal to the cancer cells, Foster and LeGendre discovered that the cancer cells were dying very quickly – within 30 minutes to an hour. Since programmed cell death takes between 16 and 24 hours, the scientists realized that something else had to be causing the cancer cells to break down and die.

LeGendre, a chemist, provided the answer: The cancer cells were being killed by their own enzymes. The oleocanthal was puncturing the vesicles inside the cancer cells that store the cell's waste – the cell's "dumpster," as Breslin called it, or "recycling center," as Foster refers to it. These vesicles, known as lysosomes are larger in cancer cells than in , and they contain a lot of waste. "Once you open one of those things, all hell breaks loose," Breslin said.

But oleocanthal didn't harm healthy cells, the researchers found. It merely stopped their life cycles temporarily – "put them to sleep," Breslin said. After a day, the healthy cells resumed their cycles.  

The researchers say the logical next step is to go beyond laboratory conditions and show that oleocanthal can kill and shrink tumors in living animals. "We also need to understand why it is that cancerous cells are more sensitive to oleocanthal than non-," Foster said.

Explore further: A taste for olive oil could provide insight into its anti-inflammatory properties

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betterexists
1 / 5 (1) Feb 16, 2015
Same way, Why NOT put a Camera on Each & Every Gun and Catch the Shooter with that clue? Record the Audio Too simultaneously.
Miniaturize EVERYTHING!
Carmen O
5 / 5 (1) Feb 24, 2015
The benefits of virgin olive oil are many, not just cancer cells and Alzheimer's. I used to have a very debilitating case of fibromyalgia until I ran across a website by people with fibromyalgia that suggested increasing the consumption of virgin olive oil. I use it almost exclusively when cooking with oil. Once I started using it all the time, my usual pain went away. I still have fibromyalgia because when people touch me in a sensitive area, it hurts but otherwise I feel no pain. I used to have to crawl up the stairs to my bedroom due to how severe the pain used to be. No one will even convince me it was not the olive oil.

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