Monounsaturated fatty acids may improve adipose dysfunction

February 4, 2015
Monounsaturated fatty acids may improve adipose dysfunction

(HealthDay)—Monounsaturated fatty acids (MUFAs) may reduce inflammation and improve insulin sensitivity in adipose tissue, according to research published online Jan. 27 in Diabetes.

Orla M. Finucane, Ph.D., of the Conway Institute of Biomedical and Biomolecular Sciences & Institute of Food & Health in Dublin, and colleagues fed mice a high-fat diet (HFD) with saturated fatty acids (SFAs) or MUFAs. The researchers compared the effects of different on biology and insulin sensitivity.

The researchers found that, compared with SFA-HFD fed mice, MUFA-HFD fed mice showed improved insulin sensitivity coincident with reduced pro-IL-1β priming, attenuated adipose IL-1β secretion, and sustained adipose AMPK activation. In addition, MUFA-HFD fed mice showed hyperplastic adipose with enhanced adipogenic potential of stromal vascular fraction and improved . Switching from SFA-HFD to MUFA-HFD did not reverse insulin resistance, but fasting plasma insulin levels were improved. An in vitro study showed that MUFA oleic acid impedes adenosine triphosphate-induced IL-1β secretion from lipopolysaccharide and SFA primed cells in an AMPK-dependent manner.

"These novel findings suggest that dietary MUFA can attenuate IL-1β mediated insulin resistance and adipose dysfunction despite obesity via preservation of AMPK activity," the authors write.

Explore further: Estrogen may improve pathway-selective insulin resistance

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Estrogen may improve pathway-selective insulin resistance

February 14, 2013
(HealthDay)—Estrogen treatment at the time of surgical menopause may reverse aspects of pathway-selective insulin resistance in the liver associated with a high-fat diet (HFD) in mice by promoting insulin action on glucose ...

Early advice on diet improves insulin sensitivity in youth

July 10, 2013
(HealthDay)—Dietary counseling, initiated with the parents at infancy and maintained as the child ages, is associated with improved insulin sensitivity at age 15 to 20, according to a study published online June 25 in Diabetes ...

Gamma-Delta T cells may play a role in insulin resistance and type 2 diabetes

January 5, 2015
New research in mice suggests that an unusual type of immune cell called "γδ T cells" may be a new drug and research target for treating or preventing type 2 diabetes caused by obesity. The research report, appearing in ...

How does DPP-4 inhibition affect liver function?

January 27, 2015
(HealthDay)—Dipeptidyl peptidase-4 (DPP-4) inhibition may attenuate hepatic steatosis and insulin resistance induced by the Western diet (WD) through hepatic lipid remodeling and modulation of hepatic mitochondrial function, ...

Fewer blood vessels in adipose tissue could explain higher risk of diabetes

October 6, 2014
Type 2 diabetes normally occurs in late middle age, but the reason is still unclear. An international team of researchers led from Karolinska Institutet have, in experiments on mice, shown that adipose tissue develops fewer ...

Pellino 3 protein may prevent development of obesity-driven diabetes

January 12, 2015
Maynooth University scientists have identified a protein in the body that may have the potential to prevent the development of obesity-driven diabetes.

Recommended for you

Poor sleep + type 2 diabetes = Slower wound healing

August 20, 2018
People with Type 2 diabetes who don't sleep well could need more time to heal their wounds, according to a new study published by researchers from the University of Tennessee, Knoxville.

Low levels of vitamin D3 and periodontitis may trigger the onset of Type 2 diabetes

August 20, 2018
In a rare study of its kind, new University of Toronto research has identified how vitamin D3 and periodontitis influence Type 2 diabetes.

Using mushrooms as a prebiotic may help improve glucose regulation

August 16, 2018
Eating white button mushrooms can create subtle shifts in the microbial community in the gut, which could improve the regulation of glucose in the liver, according to a team of researchers. They also suggest that better understanding ...

Cardiovascular disease related to type 2 diabetes can be reduced significantly

August 16, 2018
Properly composed treatment and refraining from cigarette consumption can significantly reduce the risk of cardiovascular disease resulting from type 2 diabetes, according to a study published in the New England Journal of ...

Blood test may identify gestational diabetes risk in first trimester

August 16, 2018
A blood test conducted as early as the 10th week of pregnancy may help identify women at risk for gestational diabetes, a pregnancy-related condition that poses potentially serious health risks for mothers and infants, according ...

Weight gain after smoking cessation linked to increased short-term diabetes risk

August 15, 2018
People who gain weight after they quit smoking may face a temporary increase in the risk of developing type 2 diabetes, with the risk directly proportional to the weight gain, according to a new study from Harvard T.H. Chan ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.