Nocturnal GERD tied to non-infectious rhinitis
Linus Schiöler, Ph.D., from the University of Gothenburg in Sweden, and colleagues analyzed data from 5,417 subjects participating in a multicenter longitudinal cohort. Participants completed a questionnaire in 1999 to 2001 and again in 2010 to 2012. NIR was characterized as having nasal obstruction, secretion, and/or sneezing in the absence of the common cold.
The researchers found that, over the 10-year study period, 19.1 percent of participants developed NIR. More NIR was seen in 2010 for participants reporting nocturnal gastroesophageal reflux in both 1999 and 2010 (2.8 versus 1.2 percent; P < 0.001). The number of reflux episodes/week in 1999 and the risk of having NIR in 2010 demonstrated a significant dose-response relationship (P = 0.02). Those with nocturnal GERD in 1999 (at least three episodes of nocturnal gastroesophageal reflux symptoms per week) had an increased odds of developing NIR in 2010 (odds ratio, 1.6; P = 0.03), when adjusting for age, gender, body mass index, tobacco smoke and asthma. There was an increased risk of developing NIR (P < 0.001) and nocturnal GERD associated with smoking.
"GERD should therefore be considered in patients with rhinitis of known and unknown origin," the authors write.
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