Researchers uncover a new way the body fine-tunes its immune response

Researchers uncover a new way the body fine-tunes its immune response
Scanning electron microscope image of a single human lymphocyte. Credit: Wikipedia

Microbiologists at the University of British Columbia have uncovered a novel mechanism that boosts B-cells' sensitivity to extremely small amounts of foreign molecules.

The immune system typically combines signals from B-cell antigen receptors (which distinguish foreign molecules) and Toll-like receptors (which recognize common microbial components) to mount responses.

But the new work indicates that the Toll-like receptors are able to pre-emptively initiate changes in the B-cell's structure to kickstart the antigen receptors' activity. The findings could inform vaccine design, and may explain the molecular basis for certain autoimmune diseases and B cell malignancies.

When microbial molecules bind to Toll-like receptors, filaments underlying the B cell's plasma membrane break apart. This allows B-cell antigen receptors, normally confined to compartments by the filaments, to move more freely within the membrane.

"The increase in B-cell mobility and collisions at the membrane initiates signaling to the inside of the cell, even in the absence of antigen," says UBC microbiologist Mike Gold, lead author on the paper published in Nature Communications.

"So maximum signaling can now be induced by much smaller amounts of antigen than in cells that have not been exposed to ."

The study was a collaboration between Gold, UBC mathematician Dan Coombs and UBC Cellular and Physiological Sciences' Cal Roskelley. Coombs and former UBC post-doc Raibatak Das performed mathematical analyses that quantitatively characterized how TLR signaling altered antigen receptor mobility within the .

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More information: "Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor." Nature Communications—6.6168. DOI: 10.1038/ncomms7168
Journal information: Nature Communications

Citation: Researchers uncover a new way the body fine-tunes its immune response (2015, March 12) retrieved 23 April 2021 from
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