Autosomal dominant polycystic kidney dz pain often refractory

May 9, 2015
Autosomal dominant polycystic kidney dz pain often refractory

(HealthDay)—The etiology of pain in autosomal dominant polycystic kidney disease is complex, and management of pain should be approached in a stepwise manner, according to a review published in the May issue of The Journal of Urology.

Matthew W. Tellman, from the Indiana University School of Medicine in Indianapolis, and colleagues conducted a systematic literature review of the etiology and management of pain in autosomal dominant polycystic kidney disease and anatomy of renal innervation.

The researchers found that for most patients with autosomal dominant polycystic kidney disease, pain occurs due to renal, hepatic, and mechanical origins. Patients may experience different types of pain complicating confirmation of etiology. Anatomical and histological assessment of renal innervation can help elucidate the mechanisms that can lead to renal pain. A stepwise approach is recommended for management of pain in autosomal dominant polycystic kidney disease. Due to the high incidence of acute causes of renal pain in autosomal dominant polycystic kidney disease, these must be ruled out first. Non-opioid analgesics and conservative interventions can be used first for , before considering opioid analgesics. Surgical interventions such as renal cyst decortication, , and nephrectomy can target pain from persistent renal or hepatic cysts.

"Chronic in patients with autosomal dominant is often refractory to conservative, medical, and other noninvasive treatments," the authors write.

Explore further: Most patients with chronic kidney disease may experience long-term pain

More information: Abstract
Full Text

Related Stories

Most patients with chronic kidney disease may experience long-term pain

February 19, 2015
Chronic pain is common in individuals with kidney disease, and in some patients this is associated with improper use of pain medications. The findings come from a study appearing in an upcoming issue of the Clinical Journal ...

Close monitoring of renal tumors may provide alternative to surgery

January 21, 2015
In patients likely to have surgery, close, active monitoring of small renal tumors confined to the kidneys is associated with low rates of tumor growth or death, according to a study by a researcher at the Icahn School of ...

Component of citrus fruits found to block the formation of kidney cysts

October 3, 2013
A new study published today in British Journal of Pharmacology has identified that a component of grapefruit and other citrus fruits, naringenin, successfully blocks the formation of kidney cysts.

Statins given early decrease progression of kidney disease

May 8, 2014
Results from a study by University of Colorado School of Medicine researchers show that pravastatin, a medicine widely used for treatment of high cholesterol, also slows down the growth of kidney cysts in children and young ...

Various strategies used by patients with HIV, chronic pain

February 16, 2015
(HealthDay)—For individuals with HIV and chronic pain, various pain self-management strategies are employed, including physical activity, cognitive and spiritual strategies, and substance use, according to a study published ...

Research findings point to new therapeutic approach for common cause of kidney failure

September 5, 2013
New research has uncovered a process that is defective in patients with autosomal dominant polycystic kidney disease, a common cause of kidney failure. The findings, which appear in an upcoming issue of the Journal of the ...

Recommended for you

Beware of getting a tattoo if your immune system isn't up to scratch, doctors warn

June 18, 2018
Getting a tattoo may have some unexpected complications if your immune system isn't up to scratch, warn doctors in the journal BMJ Case Reports.

Recent clinical trial finds tamsulosin not effective in kidney stone passage

June 18, 2018
The latest research into finding medications to aid the passage of ureteral or kidney stones has shown that tamsulosin is not effective for patients across the board. Previously approved to help men experiencing enlarged ...

Research finds new way to determine protection of Men B vaccine against different strains

June 18, 2018
Researchers at the University of Leicester and Meningococcal Reference Unit have developed a new approach to assess the effectiveness of the Men B vaccine, Bexsero, against different strains that cause meningococcal meningitis ...

Novel molecular target to prevent scarring of the lung blood vessels identified

June 13, 2018
Pulmonary arterial hypertension, a severe form of cardiopulmonary disease in which the arteries that transport blood from the heart to the lungs become thickened, constricted, and scarred, is a disease for which there is ...

Lineage of TB traced and compared to early human migration

June 13, 2018
A team of researchers from the University of Wisconsin, the University of Iowa and the Norwegian Institute of Public Health has carried out genetic studies of tuberculosis to learn more about its lineage and to compare it ...

Fast-acting cholera vaccine could curb outbreaks

June 13, 2018
A tricked-out cholera vaccine starts protecting against the deadly disease within a day, experiments in rabbits suggest. The rapid protection offered by this designer vaccine may one day limit the spread of cholera outbreaks, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.