Review: Fecal transplants effective weapon against C. dif

May 5, 2015
Review: fecal transplants effective weapon against <i>C. dif</i>

(HealthDay)—Fecal transplantation appears to be a safe and effective way to combat Clostridium difficile (C. difficile) infection, according to a new review published in the May 5 issue of the Annals of Internal Medicine.

The researchers looked at the findings of two randomized, controlled trials as well as 33 uncontrolled case reports involving 516 C. difficile fecal transplant patients.

The team found that in recurrent infections caused by C. difficile, the intervention is successful 85 percent of the time. Fecal transplants also helped 55 percent of patients for whom standard drug treatments didn't work.

The conclusion: Fecal transplantation appeared to be effective while prompting few short-term side effects. But the investigators cautioned that the available data is "low-strength." They also said there isn't enough evidence for drafting guidelines regarding how to determine ideal donor candidates, how to identify ideal fecal-preparation methods, or how best to deliver the sourced stool to patients.

Explore further: Fecal transplants successful for treating C. difficile infection

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Fecal transplants successful for treating C. difficile infection

March 30, 2015
Distasteful though it sounds, the transplantation of fecal matter is more successful for treating Clostridium difficile infections than previously thought.

Fecal transplant feasible for recurrent C. difficile infection

March 3, 2012
(HealthDay) -- Recurrent Clostridium difficile (C. difficile) infection (CDI) can successfully be treated in the vast majority of patients through a fecal transplantation procedure via colonoscopy, according to research published ...

A new treatment option for Clostridium difficile: Fecal transplantation

March 14, 2012
Fecal transplantation through colonoscopy is an effective treatment for recurrent Clostridium difficile infection (CDI), according to a new study in Gastroenterology, the official journal of the American Gastroenterological ...

Fecal microbiota tx feasible for recurrent C. difficile in HIV

May 22, 2013
(HealthDay)—For HIV-infected individuals with recurrent Clostridium difficile infection, fecal microbiota therapy is feasible, according to a letter published in the May 21 issue of the Annals of Internal Medicine.

New evidence supports success of fecal transplants in treatment of Clostridium difficile infection

April 9, 2015
Research published in the open access journal Microbiome offers new evidence for the success of fecal microbial transplantation (FMT) in treating severe Clostridium difficile infection (CDI), a growing problem worldwide that ...

Rapid and unexpected weight gain after fecal transplant

February 4, 2015
A woman successfully treated for a recurrent Clostridium difficile infection with stool from an overweight donor rapidly gained weight herself afterwards, becoming obese, according to a case report published in the new journal ...

Recommended for you

Breakthrough treatment for crippling jaw disease created

June 20, 2018
A first-ever tissue implant to safely treat a common jaw defect, known as temporomandibular joint dysfunction, has been successfully tested by UCI-led researchers in a large animal model, according to new findings.

New flu vaccine only a little better than traditional shot

June 20, 2018
A newer kind of flu vaccine only worked a little bit better in seniors this past winter than traditional shots, the government reported Wednesday.

Blood signature could improve early tuberculosis diagnosis

June 19, 2018
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin. Such a signature has now been developed by a team led by the Francis Crick ...

Scientists uncover a factor important for Zika virus host species restriction

June 19, 2018
Princeton University researchers Qiang Ding, Alexander Ploss, and colleagues have identified one of the mechanisms by which Zika virus (ZIKV) circumvents immune control to replicate in human cells. The paper detailing this ...

Toothpaste and hand wash may contribute to antibiotic resistance

June 19, 2018
A common ingredient in toothpaste and hand wash could be contributing to antibiotic resistance, according to University of Queensland research.

Children's immune system could hold the key to preventing sepsis

June 19, 2018
Children's immune systems could hold the key to preventing life-threatening infections and sepsis, a new study has revealed.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.