Trade-off for six weeks versus six months of triple Tx post stent

Trade-off for six weeks versus six months of triple tx post stent

(HealthDay)—For patients receiving oral anticoagulation after drug-eluting stent implantation, six weeks of triple therapy is not superior to six months of therapy with respect to net clinical outcomes, according to a study published in the April 28 issue of the Journal of the American College of Cardiology.

Katrin A. Fiedler, M.D., from the Technische Universität in Munich, and colleagues examined the effect of shortening the duration of clopidogrel therapy from six months to six weeks after drug-eluting . A total of 614 patients were randomized to six weeks or six months of clopidogrel therapy.

The researchers found that the primary end point (a composite of death, , definite stent thrombosis, stroke, or Thrombolysis In Myocardial Infarction major bleeding at nine months) occurred in 9.8 and 8.8 percent of patients in the six-week and six-month groups, respectively (hazard ratio [HR], 1.14; 95 percent confidence interval [CI], 0.68 to 1.91; P = 0.63). No significant differences were seen for the secondary combined ischemic end point (HR, 0.93; 95 percent CI, 0.43 to 2.05; P = 0.87) or the secondary bleeding end point (HR, 1.35; 95 percent CI, 0.64 to 2.84; P = 0.44).

"These results suggest that physicians should weigh the trade-off between ischemic and bleeding risk when choosing the shorter or longer duration of ," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.


Explore further

Meta-analysis finds extended DAPT related to increased mortality after DES implantation

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2015 HealthDay. All rights reserved.

Citation: Trade-off for six weeks versus six months of triple Tx post stent (2015, May 4) retrieved 6 December 2019 from https://medicalxpress.com/news/2015-05-trade-off-weeks-months-triple-tx.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
6 shares

Feedback to editors

User comments