Age-adjusted comorbidity score stratifies mortality in prostate CA

June 25, 2015
Age-adjusted comorbidity score stratifies mortality in prostate CA

(HealthDay)—An age-adjusted prostate cancer-specific comorbidity index (PCCI) can stratify the risk of long-term nonprostate cancer-related mortality, according to a study published in the July issue of The Journal of Urology.

Timothy J. Daskivich, M.D., from the David Geffen School of Medicine at the University of California-Los Angeles, and colleagues sampled 1,598 men diagnosed with between 1998 and 2004. The authors determined the risk of nonprostate cancer-related mortality associated with age at diagnosis and PCCI score in testing and validation cohorts. Risk was converted into a 10-point scoring system.

The researchers found that in the testing and validation cohorts, PCCI score and age correlated with similar hazards of other-cause mortality. Equivalent risks were seen for each six-year increase in age at diagnosis of greater than 60 years and for one additional PCCI point. The age-adjusted PCCI scores were strongly predictive of other-cause mortality. For a score of 0, 1 to 2, 3 to 4, 5 to 6, 7 to 9, and 10+, the subhazard ratios of other-cause mortality versus 0 were 2.0, 4.0, 8.7, 14.7, and 43.2, respectively; 10-year cumulative incidence of other-cause mortality was 10, 19, 35, 60, 79, and 99 percent, respectively.

"The -adjusted PCCI strongly stratifies the risk of long-term, other-cause ," the authors write. "It may be incorporated into shared decision-making to decrease overtreatment of older and chronically ill men with cancer."

One author disclosed a financial tie to WiserCare.

Explore further: Benefit of aggressive prostate CA Tx weakens as comorbidity rises

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Age, creatinine, ejection fraction predict post-MI survival

April 20, 2015

(HealthDay)—A simple age, creatinine, and ejection fraction (ACEF) score can predict one-year mortality risk in myocardial infarction 30-day survivors who underwent percutaneous coronary intervention, according to a study ...

Risk score IDs one-year mortality in elderly with NSTE-ACS

June 19, 2015

(HealthDay)—A risk score involving five covariates can predict one-year mortality risk in patients ≥75 years presenting with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS), according to a study published ...

Age-related macular degeneration, mortality linked

May 12, 2015

(HealthDay)—Age-related macular degeneration (AMD) is a predictor of poor survival, especially among women aged 80 years and older, according to a study published online May 4 in the Journal of the American Geriatrics Society.

Recommended for you

Dogs detect breast cancer from bandage: researchers

March 24, 2017

Dogs can sniff out cancer from a piece of cloth which had touched the breast of a woman with a tumour, researchers said Friday, announcing the results of an unusual, but promising, diagnostic trial.

'Jumonji' protein key to Ewing's sarcoma rampage

March 24, 2017

By the time Ewing's Sarcoma is diagnosed, primarily in teens and young adults, it has often spread from its primary site to other parts of the body, making it difficult to treat. A University of Colorado Cancer Center study ...

In a sample of blood, researchers probe for cancer clues

March 24, 2017

One day, patients may be able to monitor their body's response to cancer therapy just by having their blood drawn. A new study, led by bioengineers at UC Berkeley, has taken an important step in that direction by measuring ...

Researchers gain insight into breast cancer drug resistance

March 24, 2017

Breast cancer's ability to develop resistance to treatment has frustrated researchers and physicians and has thwarted even the latest and greatest targeted therapies. For example, after researchers identified a disease pathway ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.