Spanish scientists patent a faster and more reliable technique for diagnosing oral cancer

June 4, 2015, Universidade de Vigo
Members of the research group.

Malignant tumours of the oral cavity are the sixth leading cause of cancer-related deaths worldwide. Fast and accurate diagnosis is key to maximising the probability of successful treatment and the hope and quality of life of patients.

Investigators from the Biomedical Research Institute (IBI), in Galicia (Spain), who form part of the BIOCAPS project, have patented a faster, more reliable and less invasive for detecting carcinomas in the oral mucosa. This patent has been licensed to the company Irida Ibérica, which is currently developing a portable prototype and will fund further research by the IBI scientists to establish the exact parameters by way of in vivo trials, in other words using tissues analysed in patients.

Scientific/clinical collaboration, which is one of the main objectives of BIOCAPS to ensure research results oriented towards resolving problems in medical practice, has formed a key part of this breakthrough. Thus, the New Materials Group at IBI and the Otorhinolaryngology Department at the Hospital Povisa (Vigo) worked together to develop this new technique, which could possibly be adapted for application in the diagnosis of other common cancers, such as cervical and , in the future.

Numerous advantages

"The earliest symptom of cancer of the is the appearance of whitish or reddish lesions, which do not disappear or which may grow larger with time, on the inner surface of the oropharyngeal cavity", explains Dr. Roberto Valdés from the Hospital Povisa. These lesions subsequently become painful, either spontaneously or during chewing or swallowing, followed by the onset of oral bleeding.

In the event of the onset of such signs, the method currently used to diagnose carcinoma of the epithelial mucosal tissue in the oropharyngeal cavity (the moist tissues that cover the mouth and upper part of the throat) is observation and biopsy of those tissues with an abnormal appearance. This is therefore an invasive technique whose accuracy depends on adequate sampling of the lesion and correct interpretation of the results of the pathological analysis.

The alternative designed by the BIOCAPS researchers provides important advantages by "comprising a non- that allows tissue to be analysed in the patient, without the need for either incisions or tissue removal", as noted by Pío González, the coordinator of the New Materials Group. Moreover, it can be performed using an easy-to-handle portable device, thus allowing the technique to be used by physicians and result to be obtained immediately in the consulting room or operating theatre without the need for laboratory analyses. From a clinical viewpoint, Valdés notes that "this is a non-traumatic test as there is no need to perform biopsies, thus making it possible to perform multiple examinations in suspected patients and reach an early diagnosis of this tumour-type disease".

Indeed, the new method is expected to substantially reduce the costs and time required for diagnosis, a key factor as regards applying the treatment as soon as possible, and will also replace the subjective interpretation of results by providing an exact measure of the degree of malignancy or normality of the tissue.

The key to this is the use of an optical technique known as Raman spectroscopy, which involves irradiating the tissue with laser light to provide accurate information regarding the surface irradiated without having any harmful effects on it.

"Although it had previously been shown that Raman spectroscopy can differentiate between different functional groups characteristic of changes in living tissue, specific studies with this type of cancer had not been conducted", explains Miriam López, a researcher at IBI. "Malignancy indices such as those developed by us were also unavailable, therefore this study represents and clear and specific breakthrough in the detection of this disease with high reliability", she adds.

Prototype in late 2015

Irida Ibérica expects to have the first prototype available by the end of this year and will then fund the research that will be performed at the IBI to refine the malignancy parameters previously obtained using measurements performed in the laboratory and which this study will allow to be compared with patient samples provided by two Galician hospitals.

Once the final malignancy criteria established in the in vivo trials have been incorporated, the technique will be made available to the medical community. "It will be vital to attend conferences to present this technique and demonstrate to specialists that it is more objective and reliable as it will even allow diagnosis before the tumour becomes visible by identifying cancerous cells before they can be observed visually", explains Nikos Ekizoglou, head of projects at the company.

The research that resulted in this new diagnostic technique was conducted within the framework of the European BIOCAPS project and was partially financed with FEDER funds via the Xunta de Galicia.

Explore further: Researchers participate in the design of a future vaccine for tuberculosis

Related Stories

Researchers participate in the design of a future vaccine for tuberculosis

May 4, 2015
Researchers from BIOCAPS will collaborate with scientists from seven countries to design a future vaccine against one of the most persistent diseases worldwide, an infectious disease that provokes one death every 24 seconds: ...

New technique could improve the outcome of breast cancer surgery

September 30, 2014
A new technique will help surgeons to detect where the margins of cancerous breast tumours are during surgery, reducing the need for secondary operations in breast cancer patients.

Improving cancer treatment through better imaging technologies

March 6, 2015
Since January 2014, the HELICOID project has been developing hyperspectral imaging technologies capable of differentiating between healthy and diseased tissues. The February 2015 meeting in Brussels enabled project partners ...

New method to test breast lesions could better detect cancer, save money by reducing repeat biopsies

May 31, 2013
A newly developed, single-step Raman spectroscopy algorithm has the potential to simultaneously detect microcalcifications and enable diagnosis of the associated breast lesions with high precision, according to data published ...

'Fingerprinting' breakthrough offers improved brain tumour diagnosis

September 21, 2012
(Medical Xpress)—UK scientists have made a breakthrough in a new method of brain tumour diagnosis, offering hope to tens of thousands of people.

'Spectral histopathology' facilitates prognosis regarding tumour aggressiveness

April 20, 2015
A new diagnostic method, namely spectral histopathology, facilitates marker-free detection of individual subtypes of lung cancers. It was developed by researchers at the PURE consortium at Ruhr-Universität Bochum (RUB). ...

Recommended for you

Mutant cells colonize our tissues over our lifetime

October 18, 2018
By the time we reach middle age, more than half of the oesophagus in healthy people has been taken over by cells carrying mutations in cancer genes, scientists have uncovered. By studying normal oesophagus tissue, scientists ...

Study involving hundreds of patient samples may reveal new treatment options of leukemia

October 17, 2018
After more than five years and 672 patient samples, an OHSU research team has published the largest cancer dataset of its kind for a form of leukemia. The study, "Functional Genomic Landscape of Acute Myeloid Leukemia", published ...

A 150-year-old drug might improve radiation therapy for cancer

October 17, 2018
A drug first identified 150 years ago and used as a smooth-muscle relaxant might make tumors more sensitive to radiation therapy, according to a recent study led by researchers at The Ohio State University Comprehensive Cancer ...

Loss of protein p53 helps cancer cells multiply in 'unfavourable' conditions

October 17, 2018
Researchers have discovered a novel consequence of loss of the tumour protein p53 that promotes cancer development, according to new findings in eLife.

Researcher fighting breast cancer with light therapy

October 17, 2018
When treatment is working for a patient who is fighting cancer, the light at the end of the tunnel is easier to see.

New method uses just a drop of blood to monitor lung cancer treatment

October 17, 2018
Dr. Tasuku Honjo won the 2018 Nobel Prize in physiology or medicine for discovering the immune T-cell protein PD-1. This discovery led to a set of anti-cancer medications called checkpoint inhibitors, one of the first of ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.