Chloride levels linked to mortality in heart failure

Chloride levels linked to mortality in heart failure

(HealthDay)—Serum chloride levels at admission are associated with mortality among patients with acute decompensated heart failure (ADHF), according to a study published in the Aug. 11 issue of the Journal of the American College of Cardiology.

Justin L. Grodin, M.D., from the Cleveland Clinic, and colleagues examined the prognostic significant of sodium in relation to serum in a cohort of 1,318 patients with chronic admitted for ADHF. Findings were validated in an independent cohort of 876 ADHF patients.

The researchers observed an independent and inverse association for admission serum chloride levels during hospitalization for ADHF and long-term mortality (hazard ratio [HR] per unit change, 0.94; P < 0.001). After multivariable risk adjustment, admission chloride levels, but not sodium levels, remained independently associated with mortality (HR per unit change, 0.93; P < 0.001 and P > 0.05, respectively). Similar results were seen in the validation cohort in unadjusted and multivariable risk-adjusted analyses (HRs per unit change for mortality risk within one year, 0.93 [P < 0.001] and 0.95 [P = 0.01], respectively).

"These observations in a contemporary advanced ADHF cohort suggest that serum chloride levels at admission are independently and inversely associated with mortality," the authors write. "The prognostic value of in ADHF was diminished compared with chloride."


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Citation: Chloride levels linked to mortality in heart failure (2015, August 4) retrieved 11 December 2019 from https://medicalxpress.com/news/2015-08-chloride-linked-mortality-heart-failure.html
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