A possible cure for allergies

A possible cure for allergies
Scientists from Switzerland, Japan and the US discovered that mast cells are not only “bad guys” that initiate the allergic reaction, but also have a “good side”: They lead to the production of large amounts of T-regulatory (Treg) cells, that suppress the allergic inflammation. This could be the basis for a new way to handle allergies.

Researchers discovered a mechanism that stops the body reacting with an excessive immune reaction. This could be the basis for a new treatment.

Most people with allergies have to take medication throughout their life: Their body "thinks" that proteins from the environment are so "strange" that they elicit an . Until present, it was not possible to develop an efficient therapy so that the body "learns" to stop in an overreacting way.

Scientists from the Swiss Institute of Allergy and Asthma Research (SIAF) in Davos, from the University of Tokyo, the RIKEN Research Institute in Yokohoma, and from Stanford University recently discovered a mechanism that could be the basis for a new way to handle allergies.

Mast play a key role in the disease process in allergies: As a reaction towards an allergen – for example pollen or dust mites – they release big amounts of substances that initiate an . Study leader Hideaki Morita and his team discovered that mast cells are not only "bad guys", but also have a "good side" (see figure): They release the substance interleukin-2 that induces the production of certain called T-regulatory (Treg) cells. Treg cells can suppress the allergic inflammatory process in the airways induced by interleukin-10.

It is already known for some time that Treg cells can subdue an excessive immune response and the resulting inflammation. For example, injections with Treg cells prevented autoimmune diseases in mice. However, for Treg cell treatments one needs a large amount of these cells, which is not easy to realise. In the blood, there are just a few of them, and in vitro they are difficult to produce. Using , Treg cells could be easily produced in the laboratory in large quantities. "The mechanism that we discovered, could be the basis for a new way to handle allergies," says Hideaki Morita.


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More information: "An interleukin-33-Mast Cell-interleukin-2 Axis Suppresses Allergic Inflammation Induced by Papain-Promoting Regulatory T Cell Numbers," Immunity (2015), dx.doi.org/10.1016/j.immuni .2015.06.021
Journal information: Immunity

Provided by Swiss Institute of Allergy and Asthma Research (SIAF)
Citation: A possible cure for allergies (2015, September 8) retrieved 21 October 2020 from https://medicalxpress.com/news/2015-09-allergies.html
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