Chemoradiation for glioblastoma takes toll on brain

September 17, 2015
Chemoradiation for glioblastoma takes toll on brain

(HealthDay)—Radiation and chemotherapy can cause structural changes in the healthy brain tissue of patients with glioblastoma brain tumors, according to a study published in the Aug. 25 issue of Neurology.

The research included 14 glioblastoma patients who underwent 35 weeks of chemoradiation after having their tumors surgically removed. The patients had before and after chemoradiation, but an adequate number of images were obtained from only eight of the .

Those images revealed a significant decrease in whole volume throughout chemoradiation. The reduced amount of brain tissue became apparent within a few weeks after the start of chemoradiation and was primarily seen in gray matter. The scans also showed that the size of the brain's ventricles grew progressively larger during chemoradiation. Changes were also detected within the subventricular zone, one of two structures in which new brain cells are generated in adults.

"We were surprised to see that these changes—reduced volume and ventricular enlargement—occurred after just a few weeks of treatment and continued to progress even after radiation therapy was completed," study author Jorg Dietrich, M.D., Ph.D., of the Pappas Center for Neuro-Oncology at Massachusetts General Hospital in Boston, said in a hospital news release. "While this was a small study, these changes affected every patient at least to some degree. Now we need to investigate whether these structural changes correlate with reduced cognitive function, and whether neuroprotective strategies might be able to stop the progression of brain volume loss."

Explore further: Study reveals effects of chemoradiation in brains of glioblastoma patients

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Study reveals effects of chemoradiation in brains of glioblastoma patients

August 17, 2015
A study from Massachusetts General Hospital (MGH) Cancer Center researchers - the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients - reveals not only ...

Chemo, radiation followed by surgery improves survival in lung cancer patients

April 30, 2013
In one of the largest observational studies of its kind, researchers report that a combination of chemotherapy and radiation followed by surgery in patients with stage 3 non-small cell lung cancer improves survival.

Do antipsychotic medications affect cortical thinning?

September 3, 2015
People diagnosed with schizophrenia critically rely upon treatment with antipsychotic medications to manage their symptoms and help them function at home and in the workplace.

ASCO: Risks of whole brain radiotx may outweigh benefits

June 1, 2015
(HealthDay)—Targeted radiation in the treatment of brain metastases leads to less cognitive damage than radiation for the entire brain, while survival is similar, researchers reported Sunday at the annual meeting of the ...

Minimizing side effects from chemoradiation could help brain cancer patients live longer

April 19, 2011
Minimizing neurological side effects in patients with high-grade glioma from chemoradiation may result in improved patient survival, a new study from radiation oncologists at the Kimmel Cancer Center at Jefferson suggests. ...

When cancer makes its way to the brain

August 27, 2015
Only half of brain cancers actually start in the brain. The rest—as in the case of former President Jimmy Carter—are metastatic tumors from cancer that originated elsewhere in the body.

Recommended for you

Implant helps paralysed man walk again

September 24, 2018
Five years after he was paralysed in a snowmobile accident, a man in the US has learned to walk again aided by an electrical implant, in a potential breakthrough for spinal injury sufferers.

Study of protein 'trafficker' provides insight into autism and other brain disorders

September 22, 2018
In the brain, as in business, connections are everything. To maintain cellular associates, the outer surface of a neuron, its membrane, must express particular proteins—proverbial hands that reach out and greet nearby cells. ...

Breast milk may be best for premature babies' brain development

September 21, 2018
Babies born before their due date show better brain development when fed breast milk rather than formula, a study has found.

White matter repair and traumatic brain injury

September 20, 2018
Traumatic brain injury (TBI) is a leading cause of death and disability in the U.S., contributing to about 30 percent of all injury deaths, according to the CDC. TBI causes damage to both white and gray matter in the brain, ...

'Gut sense' is hardwired, not hormonal

September 20, 2018
If you've ever felt nauseous before an important presentation, or foggy after a big meal, then you know the power of the gut-brain connection.

Gut branches of vagus nerve essential components of brain's reward and motivation system

September 20, 2018
A novel gut-to-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation, according to research conducted at the Icahn School of Medicine at Mount ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.