Removing all visible cancer is key to treating aggressive brain tumors

September 15, 2015
Removing all visible cancer is key to treating aggressive brain tumors
Study of almost 100 children also finds greater survival rate for girls than boys after surgery.

(HealthDay)—Surgery that removes all visible cancer significantly improves the chances of survival for children with aggressive brain tumors, especially girls.

That's the finding of a study that included almost 100 children treated for high-grade glioma between 1988 and 2010. These rare brain tumors occur in fewer than one in 100,000 children and teens.

After two years, the overall survival rate was 45 percent; 25 percent had no cancer progression.

Surgery to remove all visible signs of cancer was successful in one-third of the children. Their median survival was 3.4 years, compared with 1.6 years for those who did not have all visible cancer removed. Median means half of the children lived longer, half did not.

The after successful surgery was much greater in girls, with median survival of 8.1 years. Boys had a median survival of 2.4 years.

The study is published in the September issue of the journal Neurosurgery.

Surgical removal of all visible cancer is already the standard of care, but this study reinforces its importance in improving survival, according to Dr. Jeffrey Greenfield and colleagues. Greenfield is an associate professor of neurological surgery at Weill Cornell Medical College in New York City.

High-grade gliomas account for 8 percent to 12 percent of brain tumors in children, and about 30 percent of in adults.

Explore further: Complete resection of high-grade brain cancer yields better survival in children—especially girls

More information: The U.S. National Library of Medicine has more about childhood brain tumors.

Related Stories

Complete resection of high-grade brain cancer yields better survival in children—especially girls

August 18, 2015
For children with aggressive brain cancers called high-grade gliomas (HGG), the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, ...

Gender influences survival after pediatric brain tumor removal

August 26, 2015
It's an unexpected discovery: All else being equal, girls whose rare and deadly brain tumors are fully removed live almost six years longer than boys with the same condition.

Improved survival in adult patients with low-grade brain tumors

July 1, 2015
Using clinical data collected over the past decade through a U.S. cancer registry, researchers at the University of California, San Diego School of Medicine demonstrated that significant strides have been made in improving ...

Laparoscopic surgery achieves similar survival rates in rectal cancer

April 2, 2015
(HealthDay)—Patients with localized rectal cancer may achieve similar survival rates by having minimally invasive laparoscopic surgery, instead of more invasive open surgery, according to new research published in the April ...

Clinical trial suggests combination therapy is best for low-grade brain tumors

March 10, 2015
New clinical-trial findings provide further evidence that combining chemotherapy with radiation therapy is the best treatment for people with a low-grade form of brain cancer. The findings come from a phase II study co-led ...

When cancer makes its way to the brain

August 27, 2015
Only half of brain cancers actually start in the brain. The rest—as in the case of former President Jimmy Carter—are metastatic tumors from cancer that originated elsewhere in the body.

Recommended for you

Outdoor light at night linked with increased breast cancer risk in women

August 17, 2017
Women who live in areas with higher levels of outdoor light at night may be at higher risk for breast cancer than those living in areas with lower levels, according to a large long-term study from Harvard T.H. Chan School ...

Scientists develop novel immunotherapy technology for prostate cancer

August 17, 2017
A study led by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA to directly encode protective antibodies against a cancer specific ...

Toxic formaldehyde is produced inside our own cells, scientists discover

August 16, 2017
New research has revealed that some of the toxin formaldehyde in our bodies does not come from our environment - it is a by-product of an essential reaction inside our own cells. This could provide new targets for developing ...

Cell cycle-blocking drugs can shrink tumors by enlisting immune system in attack on cancer

August 16, 2017
In the brief time that drugs known as CDK4/6 inhibitors have been approved for the treatment of metastatic breast cancer, doctors have made a startling observation: in certain patients, the drugs—designed to halt cancer ...

Researchers find 'switch' that turns on immune cells' tumor-killing ability

August 16, 2017
Molecular biologists led by Leonid Pobezinsky and his wife and research collaborator Elena Pobezinskaya at the University of Massachusetts Amherst have published results that for the first time show how a microRNA molecule ...

Popular immunotherapy target turns out to have a surprising buddy

August 16, 2017
The majority of current cancer immunotherapies focus on PD-L1. This well studied protein turns out to be controlled by a partner, CMTM6, a previously unexplored molecule that is now suddenly also a potential therapeutic target. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.