Fish oil supplementation doesn't cut inflammatory markers

Fish oil supplementation doesn't cut inflammatory markers

(HealthDay)—For healthy adults, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation does not reduce common markers of systemic inflammation, according to a study published online Oct. 26 in the Journal of Internal Medicine.

Matthew F. Muldoon, M.D., from the University of Pittsburgh School of Medicine, and colleagues conducted a double-blind, placebo-controlled clinical trial to examine whether EPA+DHA supplementation reduces common biomarkers of chronic, . Two hundred sixty-one healthy individuals aged 30 to 54 years were enrolled and randomized to 18 weeks of providing 1,400 mg per day EPA+DHA, or to a matching placebo.

The researchers observed a 64 percent increase in red blood cell EPA+DHA in the active treatment group, while supplementation had no effect on serum C-reactive protein and interleukin-6 (P ≥ 0.20). Across subgroups and with and without imputed values the findings were consistent. Ex vivo production of four pro-inflammatory cytokines was not altered with EPA+DHA supplementation (P ≥ 0.20).

"Supplementation with 1,400 mg EPA+DHA did not reduce common markers of systemic inflammation in healthy adults," the authors write.

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