What is the role of psychological factors in nausea during cancer therapy?

A study in the current issue of Psychotherapy and Psychosomatics sheds new light on the relationship between psychological factors and nausea and vomiting during chemotherapy of cancer.

Chemotherapy-induced and vomiting (CINV) continue to be a distressing problem still reported by , with on quality of life (QoL). The Authors aimed to prospectively explore the association of psychosocial variables, including , maladaptive coping styles and the doctor-patient relationship, with CINV and QoL among cancer outpatients. A prospective study was conducted on 302 consecutive cancer patients (response rate 80.9%) in Austria, Italy and Spain.

The Distress Thermometer (DT), the Mini-Mental Adjustment to Cancer (Mini-MAC), and the Patient Satisfaction with Doctor Questionnaire (PSQ) were used to assess psychosocial variables before chemotherapy. In the 5 days after chemotherapy, CINV was examined by using a daily diary, and the Functional Living Index for Emesis (FLIE) was used to assess QoL. Results show that more than half of the patients reported nausea (54%), and a small percentage reported vomiting (14%). CINV had a negative impact on QoL (FLIE caseness, p < 0.01). Maladaptive coping (i.e. hopelessness-helplessness and anxious preoccupation) and emotional distress were associated with CINV (p < 0.05) and poorer QoL (p < 0.05). In logistic regression analysis, nausea was predicted by Mini-MAC/H (OR = 1.1, p = 0.03) and younger age (OR = 0.97, p = 0.04); negative impact on QoL was predicted by grade of chemotherapy emetogenesis (OR = 1.7, p < 0.01) and Mini-MAC/H (OR = 1.2, p = 0.04).

The Authors concluded that screening and assessment of psychological variables, especially coping, could help in identifying cancer patients at risk for chemotherapy-induced nausea, in spite of the use of antiemetic treatment.


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More information: Luigi Grassi et al. Role of Psychosocial Variables on Chemotherapy-Induced Nausea and Vomiting and Health-Related Quality of Life among Cancer Patients: A European Study, Psychotherapy and Psychosomatics (2015). DOI: 10.1159/000431256
Journal information: Psychotherapy and Psychosomatics

Provided by Journal of Psychotherapy and Psychosomatics
Citation: What is the role of psychological factors in nausea during cancer therapy? (2015, November 13) retrieved 10 August 2020 from https://medicalxpress.com/news/2015-11-role-psychological-factors-nausea-cancer.html
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