Clozapine benefits those with tx-resistant schizophrenia

December 1, 2015
Clozapine benefits those with tx-resistant schizophrenia

(HealthDay)—Clozapine reduces symptoms in patients with schizophrenia who don't benefit from other antipsychotic medications, according to research published online Nov. 6 in The American Journal of Psychiatry.

The findings were culled from an analysis of Medicaid data on 6,246 patients with treatment-resistant . The researchers assessed outcomes of a cohort of patients with schizophrenia and evidence of treatment resistance that initiated clozapine (3,123 patients) and in a propensity score-matched cohort that initiated a standard antipsychotic (3,123 patients).

The researchers found that those on clozapine had fewer hospitalizations, stayed on their new medication longer, and were less likely to need to use additional antipsychotics.

"These results give clinicians important guidance for how to help an extremely vulnerable group of people," study author T. Scott Stroup, M.D., M.P.H., a professor of psychiatry at the Columbia University Medical Center in New York City and a research psychiatrist at New York State Psychiatric Institute, said in a Columbia news release. "By helping individuals with treatment-resistant schizophrenia get effective treatment sooner, we can expect better outcomes."

Explore further: Better options for people with treatment-resistant schizophrenia

More information: Full Text (subscription or payment may be required)

Related Stories

Better options for people with treatment-resistant schizophrenia

November 6, 2015
In real-world settings, patients with schizophrenia whose symptoms do not respond to standard antipsychotic medications have better outcomes if they are switched to clozapine instead of another standard antipsychotic. They ...

Antipsychotics initiated frequently and used for long term in Alzheimer's patients

October 14, 2015
Antipsychotic drugs are initiated in patients with Alzheimer's disease (AD) more frequently than in the general population - already 2-3 years before the Alzheimer's diagnosis, according to a new study from the University ...

Do antipsychotic medications affect cortical thinning?

September 3, 2015
People diagnosed with schizophrenia critically rely upon treatment with antipsychotic medications to manage their symptoms and help them function at home and in the workplace.

Researchers use brain scans to predict response to antipsychotic medications

August 28, 2015
Investigators at The Feinstein Institute for Medical Research have discovered that brain scans can be used to predict patients' response to antipsychotic drug treatment. The findings are published online in the latest issue ...

Research may explain why some people with schizophrenia do not respond to treatment

November 29, 2012
(Medical Xpress)—New research suggests that the molecular mechanism leading to schizophrenia may be different in patients who fail to respond to anti-psychotic medication compared to patients who do respond.

Recommended for you

Color of judo uniform has no effect on winning

February 22, 2018
New research on competitive judo data finds a winning bias for the athlete who is first called, regardless of the colour of their uniform. This unique study, published in Frontiers in Psychology, puts to rest the debate on ...

Infants are able to learn abstract rules visually

February 22, 2018
Three-month-old babies cannot sit up or roll over, yet they are already capable of learning patterns from simply looking at the world around them, according to a recent Northwestern University study published in PLOS One.

Antidepressants are more effective than placebo at treating acute depression in adults, concludes study

February 22, 2018
Meta-analysis of 522 trials includes the largest amount of unpublished data to date, and finds that antidepressants are more effective than placebo for short-term treatment of acute depression in adults.

Smartphones are bad for some teens, not all

February 21, 2018
Is the next generation better or worse off because of smartphones? The answer is complex and research shows it largely depends on their lives offline.

Researchers uncover novel mechanism behind schizophrenia

February 21, 2018
An international team of researchers led by a Case Western Reserve University School of Medicine scientist has uncovered a novel mechanism in which a protein—neuregulin 3—controls how key neurotransmitters are released ...

Self-compassion may protect people from the harmful effects of perfectionism

February 21, 2018
Relating to oneself in a healthy way can help weaken the association between perfectionism and depression, according to a study published February 21, 2018 in the open-access journal PLOS ONE by Madeleine Ferrari from Australian ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.