Sustained aerobic exercise increases adult neurogenesis in the brain

February 8, 2016, Academy of Finland

It may be possible to increase the neuron reserve of the hippocampus – and thus improve preconditions for learning – by promoting neurogenesis via sustained aerobic exercise such as running

Aerobic exercise, such as , has positive effects on brain structure and function, for example, the generation of neurons (neurogenesis) in the hippocampus, a brain structure important in learning. It has been unclear whether high-intensity interval training (HIT), referring to alternating short bouts of very intense anaerobic exercise with recovery periods, or anaerobic resistance training has similar effects on hippocampal neurogenesis in adulthood. In addition, individual genetic variation in the overall response to physical exercise likely plays a part in the effects of exercise on adult neurogenesis but is less studied.

Researchers from the Department of Psychology and from the Department of Biology of Physical Activity at the University of Jyväskylä studied the effects of sustained running exercise, HIT and resistance training on adult hippocampal neurogenesis in adult male rats. In addition to the commonly used Sprague-Dawley rats, rat lines developed by collaborators at the University of Michigan were also used: Rats with a genetically high response to (HRT) and those with a low response to aerobic training (LRT). The exercise training period was 6 to 8 weeks (running, HIT or ) during which control animals of the same rat line/strain remained in sedentary conditions in the home cage.

The results indicate that the highest number of new hippocampal neurons was observed in rats that ran long distances and that also had a genetic predisposition to benefit from : Compared to sedentary animals, HRT that ran voluntarily on a running wheel had 2-3 times more new hippocampal neurons at the end of the experiment. Resistance training had no such . Also the effects of HIT were minor. To conclude, only sustained aerobic exercise improved hippocampal neurogenesis in adult animals.

The result is important because, according to previous research, the new hippocampal neurons produced as a result of neurogenesis are needed among other things for learning temporally and/or spatially complex tasks. It is possible that by promoting neurogenesis via sustained aerobic exercise, the neuron reserve of the hippocampus can be increased and thus also the preconditions for learning improved – also in humans.

Explore further: Study highlights the importance of physical activity and aerobic exercise for healthy brain function

More information: Miriam S. Nokia et al. Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained, The Journal of Physiology (2016). DOI: 10.1113/JP271552

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