Distinct demographics for persistent A-fib from onset

March 24, 2016

(HealthDay)—Patients with persistent atrial fibrillation (AF) from the onset (PsAFonset) have distinct demographics and poorer clinical outcome, according to a study published online March 23 in JACC: Clinical Electrophysiology.

Han S. Lim, M.B.B.S., Ph.D., from the Hôpital Cardiologique du Haut-Lévêque in Bordeaux, France, and colleagues enrolled referred for PsAF ablation from three centers. They compared 129 consecutive patients with PsAFonset with 231 patients with PsAF that progressed from paroxysmal AF. In addition, they characterized AF drivers using noninvasive mapping in 90 patients (30 PsAFonset and 60 controls).

The researchers found that patients with PsAFonset were younger, more obese, more often males, more often had hypertension, and had larger left and right atria. PsAFonset patients had a shorter AF-cycle-length, higher degree of fractionation, and lower endocardial voltage. A significantly higher number of reentrant driver regions and extra-pulmonary vein regions harboring reentrant drivers was seen among PsAFonset patients; in contrast, more focal driver regions were seen among controls. The PsAFonset group had lower acute AF termination rate. Patients with PsAFonset had significantly higher AF, atrial tachycardia (AT), and AF/AT recurrence rates during a mean follow-up of 17 ± 11 months from the last procedure.

"The findings highlight the importance of defining criteria for early detection of atrial substrate disease," the authors write.

Several authors disclosed financial ties to the pharmaceutical, medical device, and medical technology industries.

Explore further: Genotype doesn't predict A-fib in hypertrophic cardiomyopathy

More information: Full Text (subscription or payment may be required)

Related Stories

Genotype doesn't predict A-fib in hypertrophic cardiomyopathy

March 21, 2016
(HealthDay)—For patients with hypertrophic cardiomyopathy (HC), genotype does not predict onset or severity of atrial fibrillation (AF), according to a study published in the April 1 issue of The American Journal of Cardiology.

Age impacts outcomes after ablation for atrial fibrillation

October 16, 2015
(HealthDay)—Age significantly impacts long-term outcomes after catheter ablation for atrial fibrillation (AF), according to a study published online Oct. 7 in the Journal of Cardiovascular Electrophysiology.

A-fib recurrence common five years after ablation

April 17, 2015
(HealthDay)—Most patients with atrial fibrillation (AF) and systolic heart failure who undergo ablation have AF recurrence at five years, according to a study published in the April issue of the Journal of Cardiovascular ...

Multiple repeat procedures seem beneficial in A-fib recurrence

May 4, 2015
(HealthDay)—Most patients experience benefit after three or more catheter ablation procedures for atrial fibrillation (AF), according to a study published in the April issue of the Journal of Cardiovascular Electrophysiology.

In ablation for persistent atrial fibrillation, 'less may be more'

September 2, 2014
In patients with persistent atrial fibrillation (AF) - an abnormal heart rhythm – treating only the pulmonary veins with a procedure called ablation resulted in reasonable outcomes without the need to treat other areas ...

Flu vaccine shows promise for reducing risk of influenza-associated atrial fibrillation

February 2, 2016
Influenza is significantly associated with an increased risk of new-onset atrial fibrillation, which could be reduced through influenza vaccination, according to new findings reported HeartRhythm.

Recommended for you

New link found between alcohol, genes and heart failure

May 25, 2018
The researchers investigated faulty versions of a gene called titin which are carried by one in 100 people or 600,000 people in the UK.

Low-dose aspirin could help pregnant women with high blood pressure avoid a dangerous condition

May 25, 2018
A daily dose of aspirin could help pregnant women in the first stage of high blood pressure avoid a condition that puts both mother and baby in danger, according to a new study.

Study examines the rise of plaque in arteries

May 25, 2018
The accumulation of cholesterol plaques in artery walls can lead to atherosclerosis, or the hardening of arteries that contributes to heart attacks and strokes. In a new study, Yale researchers investigate how plaque cells ...

Study shows in-home therapy effective for stroke rehabilitation

May 24, 2018
In-home rehabilitation, using a telehealth system and supervised by licensed occupational/physical therapists, is an effective means of improving arm motor status in stroke survivors, according to findings presented by University ...

New guidelines mean 1 in 3 adults may need blood pressure meds

May 23, 2018
(HealthDay)—One out of every three U.S. adults has high blood pressure that should be treated with medication, under guidelines recently adopted by the two leading heart health associations.

Surgery involving ultrasound energy found to treat high blood pressure

May 23, 2018
An operation that targets the nerves connected to the kidney has been found to significantly reduce blood pressure in patients with hypertension, according to the results of a clinical trial led in the UK by Queen Mary University ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.