Lead exposure changes gut microbiota, increases chance for obesity

March 10, 2016

Exposure to lead during early development can alter the the gut microbiota, increasing the chances for obesity in adulthood, researchers from the University of Michigan School of Public Health have found.

Adult male mice exposed to during gestation and lactation were 11 percent larger than those not exposed, due to differences in their , which is the ecological community of microorganisms within the body.

"Early life exposure to lead causes a long lasting impact on gut microbiome, and the change of gut microbiome may partially contribute to the increased body weight in adult life," said lead author Chuanwu Xi, associate professor of environmental health science.

Lead was added to the drinking water of female mice prior to breeding through nursing their young. Once weaned, the offspring were raised to adulthood without additional exposure, and then tested for lead effects acquired from their mothers.

"The lead levels in the mouse mothers were carefully designed to be within human population exposure levels. Our lowest dose is near the current U.S. Centers for Disease Control and Prevention's blood lead action level of 5 micrograms per deciliter, while the higher dose mirrors exposure levels during the 1960s and 70s," said Dana Dolinoy, U-M associate professor of and of nutrition sciences. "Since we are investigating the effects of the developmental origins of disease, it is important to evaluate current and historically relevant lead levels."

Lead is found throughout the environment in natural and man-made settings. For decades, researchers have found many health problems associated with exposure, even at levels lower than the threshold for safety set by the CDC. Most previous studies have dealt with ingestion and inhalation.

"We investigated more specifically the role of in the health impact upon lead in this study," Xi said.

Research has shown that large numbers of bacteria live in animal intestines, and the range of diversity in these microbes, and the balance of various organisms, is increasingly known to be tied to health.

In this study that used deep DNA sequencing of bacterial specific genes, the guts of both males and females exposed to lead had all of the similar complexity in microbiota as those not exposed. The differences were in the balance of the different groups of microorganisms.

For example, both adult males and females exposed to lead during had fewer aerobes and significantly more anaerobes, suggesting a changing microenvironment of the gut.

"In both males and females developmental lead impacted the adult microbiome. We only observed adult onset obesity in the males, but females may have shown effects on obesity if we had followed them longer," Dolinoy said.

Explore further: Early diet of infants, not maternal obesity, influences development of gut microbiome

Related Stories

Lead linked to obesity in mice exposed by mothers

August 8, 2014

When we think of ill effects from lead exposure various neurologic problems usually come to mind. Now researchers at the University of Michigan say another health impact can be added to the list: obesity.

A gut check for PCOS-related obesity

March 8, 2016

Modifying gut bacteria could be a treatment option for some of the symptoms associated with the widespread disease polycystic ovary syndrome (PCOS), according to a recent study by San Diego State University researchers in ...

Recommended for you

Survivors of childhood brain tumors have increased body fat

March 24, 2017

McMaster University researchers have discovered that while survivors of childhood brain tumours have a similar Body Mass Index (BMI) to healthy children with no cancer, they have more fat tissue overall, and especially around ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.