Medical marijuana reduces use of opioid pain meds, decreases risk for some with chronic pain

March 23, 2016 by Laurel Thomas Gnagey

Patients using medical marijuana to control chronic pain reported a 64 percent reduction in their use of more traditional prescription pain medications known as opioids, a University of Michigan study finds.

The 185 patients from a medical marijuana dispensary in Ann Arbor also reported fewer side effects from their medications and a 45-percent improvement in quality of life since using to manage pain.

Researchers from the U-M School of Public Health and Medical School said their results suggest that for some people, may be an alternative to more common prescription painkillers at a time when national health leaders are asking the medical community to cut back on prescribing drugs like Vicodin and OxyContin.

"We're in the midst of an opioid epidemic and we need to figure out what to do about it," said Kevin Boehnke, lead author of the study and doctoral student in the School of Public Health's Department of Environmental Health Sciences. "I'm hoping our research continues a conversation of cannabis as a potential alternative for opioids."

Just last week, the Centers for Disease Control and Prevention issued 12 recommended guidelines for prescribing opioids, saying prescriptions for them have quadrupled since 1999, and that 40 people die every day from an overdose of these drugs.

"We are learning that the higher the dose of opioids people are taking, the higher the risk of death from overdose. This magnitude of reduction in our study is significant enough to affect an individual's risk of accidental death from overdose," said study senior author Dr. Daniel Clauw, professor of pain management anesthesiology at the U-M Medical School.

Surveys were conducted from November 2013 to February 2015.

The researchers originally set out to find out if cannabis use was more effective for sufferers with severe centralized chronic pain, for whom the opioids have not always worked well.

"We hypothesized that cannabis might be particularly effective for the type of pain seen in conditions such as fibromyalgia, since there are many studies suggesting that synthetic cannabinoids work in these conditions," Clauw said. "We did not see this because the patients in this study rated cannabis to be equally effective for those with different pain severity."

It was the patients with less severe who reported better quality of life and less use of .

"We would caution against rushing to change current clinical practice towards cannabis, but note that this study suggests that cannabis is an effective pain medication and agent to prevent opioid overuse," Boehnke said.

At present, 23 states and the District of Columbia have legalized cannabis for medical purposes and four states allow it for recreational use.

The researchers said population level research has shown a reduction in opioid use in states where is legal, but the U-M study is one of the first to look at individual patterns of use. A study also released this month from Israel followed people for six months and found a 44-percent reduction in opioid use.

The researchers said one limitation of their study, however, is that it was conducted with people at a dispensary who are presumed to be believers in the medical benefits of marijuana. These participants were surveyed after they had been using marijuana, which may decrease the accuracy of their recollections. The team plans to continue research with this population but also conduct studies with patients who have not yet tried marijuana for pain management.

Explore further: Substance abuse risk not greater in those using medical marijuana with prescribed opioids

More information: Kevin F. Boehnke et al. Medical cannabis associated with decreased opiate medication use in retrospective cross-sectional survey of chronic pain patients, The Journal of Pain (2016). DOI: 10.1016/j.jpain.2016.03.002

The CDC Guideline for Prescribing Opioids for Chronic Pain, United States, 2016: www.cdc.gov/media/dpk/2016/dpk … tion-guidelines.html

Related Stories

Substance abuse risk not greater in those using medical marijuana with prescribed opioids

May 18, 2015
Among people who use medical cannabis for chronic pain, those who also take prescription pain medications are not at increased risk for serious alcohol and other drug involvement, according to a study in the May issue of ...

Research shows 25 percent fewer opioid-related deaths in states allowing medical marijuana

August 25, 2014
On average, states allowing the medical use of marijuana have lower rates of deaths resulting from opioid analgesic overdoses than states without such laws. Opioid analgesics, such as OxyContin, Percocet and Vicodin, are ...

Limit opioid painkiller prescriptions, US regulators say

March 16, 2016
US health authorities issued guidelines Tuesday to limit prescribing opioid painkillers, in an attempt to help curb an epidemic of overdoses that kills more than 40 Americans every day.

Physicians respond to new CDC opioid guidelines

March 21, 2016
(HealthDay)—Physicians have responded to the new U.S. Centers for Disease Control and Prevention's clinical guidelines for prescribing opioids, according to a report published by the American Medical Association (AMA).

Medical marijuana seems safe for chronic pain patients, study finds

October 7, 2015
(HealthDay)—Medical marijuana appears mostly safe for treating chronic pain, at least among people with some experience using the drug, a new study suggests.

Opioid prescribing for chronic pain—achieving the right balance through education

January 27, 2016
In recent decades, the United States has seen a dramatic increase in opioid prescribing for chronic pain. That growth has been associated with increasing misuse of these medications, leading to alarming increases in unintentional ...

Recommended for you

Fighting opioid addiction in primary care—new study shows it's possible

October 18, 2017
For many of the 2 million Americans addicted to opioids, getting good treatment and getting off prescription painkillers or heroin may seem like a far-off dream.

With no morphine, 25 million die in pain each year: report

October 13, 2017
Every year, some 25 million people—one in ten of them children—die in serious pain that could have been alleviated with morphine at just a few cents per dose, researchers said Friday.

Study finds few restrictions on Rx opioids through Medicare

October 9, 2017
Medicare plans place few restrictions on the coverage of prescription opioids, despite federal guidelines recommending such restrictions, a new Yale study finds. The research results highlight an untapped opportunity for ...

Nocebo effect: Does a drug's high price tag cause its own side effects?

October 5, 2017
Pricey drugs may make people more vulnerable to perceiving side effects, a new study suggests—and the phenomenon is not just "in their heads."

Pre-packaged brand version of compounded medication to prevent preterm births costs 5,000 percent more

October 2, 2017
Preventing a preterm birth could cost as little as $200 or as much as $20,000, depending on which one of two medications a doctor orders, according to a new analysis from Harvard Medical School.

Cancer drugs' high prices not justified by cost of development, study contends

September 12, 2017
(HealthDay)— Excusing the sky-high price tags of many new cancer treatments, pharmaceutical companies often blame high research and development (R&D) costs.

2 comments

Adjust slider to filter visible comments by rank

Display comments: newest first

speckintime
not rated yet Mar 23, 2016
Most people unless they suffer from chronic pain don't have a clue how unbearable life can be.

They don't understand what it is to not be able to sleep through the night without waking up in agony or what it feels like to have the pain creep into your dreams.

They don't understand what it feels like when even the simplest things you used to take for granted become ordeals.

They don't understand what it feels like when life goes on around you and you are stuck in this shell of agony.

They don't understand the frustration when doctors either can't or refuse to help you and they don't understand the fear of what if it gets worse.

They don't understand the hate and anger you feel when politicians deny you the one thing that could really change your life.
perrysloope
not rated yet Mar 23, 2016
As a long time chronic pain sufferer in Georgia, I don't have the option to use a substance that is nontoxic, (no one had died using it), not physically addictive, and has no bad side effects like opiods do. That substance is cannabis. In fact the state of Georgia will throw you in prison if you try to use it. We do not have the sharpest tools in the shed governing this state. Most are just plain stupid or corrupt.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.