Omalizumab decreases colds in inner-city children with asthma, study reports

March 6, 2016, NIH/National Institute of Allergy and Infectious Diseases

Treatment with omalizumab significantly decreases the number of colds in inner-city children with allergic asthma, researchers reported at a press conference today at the American Academy of Allergy, Asthma and Immunology (AAAAI) 2016 Annual Meeting in Los Angeles. Omalizumab, sold under the brand name Xolair, is an injectable antibody that can be used to treat asthma cases not controlled by inhaled corticosteroids.

These findings are a secondary result from the Preventative Omalizumab or Step-up Therapy for Severe Fall Exacerbations (PROSE) study conducted through the Inner-City Asthma Consortium (ICAC). ICAC is an asthma research program supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

In this randomized trial, researchers gave 478 children living in cities throughout the United States three types of during the fall, a season when colds are common and tend to worsen. The control group received guidelines-based asthma care, while two additional groups received this care with additional treatment of either fluticasone or omalizumab. Fluticasone is an inhaled corticosteroid sold under the brand name Flovent. The children's caregivers then monitored them for cold symptoms, such as runny nose, cough and sore throat. Based on these reports, researchers identified a total of 1,034 symptomatic colds and found that children who received omalizumab experienced a 27 percent decrease in cold incidence compared to children receiving only guidelines-based asthma care. Children who received fluticasone did not experience a significant change in cold incidence.

This study builds upon previous ICAC studies that showed that long- and short-term treatment with omalizumab decreases seasonal attacks in inner-city 6 to 17 years of age. Researchers do not yet know how omalizumab decreases colds in this specific population. However, research shows that omalizumab targets and reduces levels of an antibody known as immunoglobulin E, or IgE. Data from previous studies indicate that lower IgE levels are associated with higher interferon responses, which are known to be important in protecting against viruses, such as those that cause cold symptoms.

Explore further: New research on preventing fall asthma exacerbations

Related Stories

New research on preventing fall asthma exacerbations

January 14, 2016
Experts from Children's Hospital Colorado (Children's Colorado) co-led a team of researchers in studying new approaches to reducing fall asthma exacerbations in pediatric patients. Their findings were released online in late ...

Biologics for asthma: Attacking the source of the disease, not the symptoms

November 5, 2015
Imagine you suffer from severe asthma, and you've tried every treatment available, but nothing has worked. You still can't breathe. Then a new therapy comes along that attacks the source of the asthma, as opposed to the symptoms, ...

Better targeting of treatment gives hope to people with severe asthma

March 2, 2016
Around five million people in the UK are currently being treated for asthma. Of these, a quarter of a million are unable to get good control of their condition, resulting in frequent, severe, or even life-threatening attacks. ...

Common colds at school a primary driver of asthma hospitalizations for children

February 8, 2016
The most dangerous times of year for children with asthma are soon after their schools reopen after a break, and a new study finds that cold viruses are largely to blame.

New inhaled drug shows promise against asthma, allergies

July 2, 2014
A new inhaled medication has the potential to treat mild asthma and allergies by interrupting the production of an immune system protein that triggers allergic reactions, a new study reports.

Recommended for you

A Trojan Horse delivery for treating a rare, potentially deadly, blood-clotting disorder

September 21, 2018
In proof-of-concept experiments, University of Alabama at Birmingham researchers have highlighted a potential therapy for a rare but potentially deadly blood-clotting disorder, TTP. The researchers deliver this therapeutic ...

Study shows surprise low-level ozone impact on asthma patients

September 21, 2018
A new study led by UNC School of Medicine researchers indicates that ozone has a greater impact on asthma patients than previously thought. The study, published in the Journal of Allergy and Clinical Immunology, recruited ...

Cancer immunotherapy might benefit from previously overlooked immune players

September 20, 2018
Cancer immunotherapy—efforts to boost a patient's own immune system, allowing it to better fight cancer cells on its own—has shown great promise for some previously intractable cancers. Yet immunotherapy doesn't work ...

Gut fungus exacerbates asthma in antibiotic-treated mice

September 20, 2018
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease, according to a study published September 20 in the open-access journal PLOS Pathogens by ...

Paracetamol use in infancy is linked to increased risk of asthma in some teenagers

September 17, 2018
Children who take paracetamol during their first two years of life may be at a higher risk of developing asthma by the age of 18, especially if they have a particular genetic makeup, according to new research presented at ...

Cord blood clue to respiratory diseases

September 15, 2018
New research has found children born in the last three months of the year in Melbourne may have a greater risk of developing respiratory diseases such as asthma.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.