Selective biomarkers can ID risk of impaired glucose tolerance

Selective biomarkers can ID risk of impaired glucose tolerance
Selective biomarkers can identify the risk of isolated impaired glucose tolerance, according to a study published online April 5 in Diabetes Care.

(HealthDay)—Selective biomarkers can identify the risk of isolated impaired glucose tolerance (iIGT), according to a study published online April 5 in Diabetes Care.

Jeff Cobb, Ph.D., from Metabolon Inc. in Durham, N.C., and colleagues performed targeted metabolomics with 23 metabolites previously associated with dysglycemia using fasting plasma samples from individuals without diabetes at the time of an oral test (OGTT). Participants were included from two observational cohorts: relationship between and cardiovascular disease (RISC) and diabetes mellitus and vascular health initiative (DMVhi). Validation of selective biomarkers was conducted in the Botnia study.

The researchers found that α-hydroxybutyric acid (α-HB) was most strongly associated with iIGT (odds ratios, 2.54 in RISC and 2.75 in DMVhi); there was no significant correlation with isolated impaired fasting glucose (iIFG). On validation in the Botnia study, α-HB was selectively associated with iIGT (odds ratio, 2.03); no significant correlation was seen for iIFG. Selective biomarkers for iIGT also included linoleoyl-glycerophosphocholine (L-GPC) and . In all three cohorts, addition of α-HB, L-GPC, and oleic acid to age, sex, , and fasting glucose significantly improved the area under the curve in multivariate IGT prediction models.

"These biomarkers can be used in predictive models to identify subjects with IGT without performing an OGTT," the authors write.

Several authors disclosed financial ties to health care and biopharmaceutical companies, including Metabolon, which funded the study.

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Journal information: Diabetes Care

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Citation: Selective biomarkers can ID risk of impaired glucose tolerance (2016, April 8) retrieved 22 July 2024 from https://medicalxpress.com/news/2016-04-biomarkers-id-impaired-glucose-tolerance.html
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