Researchers unearthed more evidence that replacing butter with vegetable oils is not beneficial for cardiac health

April 13, 2016
Oil extracted from safflower seeds are used mainly in margarine and cooking oil. Credit: USDA.

A research team led by scientists at the UNC School of Medicine and the National Institutes of Health has unearthed more evidence that casts doubt on the traditional "heart healthy" practice of replacing butter and other saturated fats with corn oil and other vegetable oils high in linoleic acid.

The findings, reported today in the British Medical Journal, suggest that using high in linoleic acid might be worse than using butter when it comes to preventing , though more research needs to be done on that front. This latest evidence comes from an analysis of previously unpublished of a large controlled trial conducted in Minnesota nearly 50 years ago, as well as a broader analysis of published data from all similar trials of this dietary intervention.

The analyses show that interventions using linoleic acid-rich oils failed to reduce heart disease and overall mortality even though the intervention reduced . In the Minnesota study, participants who had greater reduction in serum cholesterol had higher rather than lower risk of death.

"Altogether, this research leads us to conclude that incomplete publication of important data has contributed to the overestimation of benefits - and the underestimation of potential risks - of replacing saturated fat with vegetable oils rich in linoleic acid," said co-first author Daisy Zamora, PhD, a researcher in the Department of Psychiatry at the UNC School of Medicine.

Along with corn oil, linoleic acid-rich oils include safflower oil, soybean oil, sunflower oil, and cottonseed oil.

The belief that replacing saturated fats with vegetable oils improves heart health dates back to the 1960s, when studies began to show that this dietary switch lowered blood cholesterol levels. Since then, some studies, including epidemiological and animal studies, have suggested that this intervention also reduces and related mortality. In 2009, the American Heart Association reaffirmed its view that a diet low in saturated fat and moderately high (5-10 percent of daily calories) amounts of linoleic acid and other omega-6 unsaturated fatty acids probably benefits the heart.

However, randomized controlled trials - considered the gold standard for medical research - have never shown that linoleic acid-based dietary interventions reduce the risk of heart attacks or deaths.

The largest of these trials, the Minnesota Coronary Experiment (MCE), was conducted by researchers at the University of Minnesota between1968 and 1973. It enrolled 9,423 patients in six state mental hospitals and one state-run nursing home. Its results did not appear in a medical journal until 1989. The investigators reported then that a switch to corn oil from butter and other saturated fats did lower cholesterol levels but made no difference in terms of heart attacks, deaths due to heart attacks, or overall deaths.

In the course of investigating the health effects of linoleic acid-rich oils, the team of investigators led by Chris Ramsden, a medical investigator at the National Institutes of Health, came across the MCE study and the 1989 paper.

"Looking closely, we realized that some of the important analyses that the MCE investigators had planned to do were missing from the paper," Zamora said.

With the help of Robert Frantz, the son of the deceased MCE principal investigator, the team was able to recover much of the raw data from the study, which had been stored away for decades in files and on magnetic tapes. The team also found some trial data and analyses in a University of Minnesota master's degree thesis written by written by Steven K. Broste, a student of one of the original investigators.

Using the recovered data to perform analyses that had been pre-specified by the MCE investigators but never published, the team confirmed the cholesterol-lowering effect of the dietary intervention. But they also found that in the recovered autopsy records, the corn oil group had almost twice the number of heart attacks as the control group.

Perhaps most strikingly, graphed summaries contained in Broste's thesis indicated that in the intervention group, women and patients older than 65 experienced roughly 15 percent more deaths during the trial, compared to their control group counterparts.

"We did not recover the individual patient data underlying those graphs and so we couldn't determine whether those differences were statistically significant," said Zamora.

She also cautioned that the other analyses were based on only partial recovery of patient data from the MCE files, so it would be premature to conclude from them that replacing saturated fats with corn oil is actually harmful to heart health.

In a much-cited study published in 2013, however, Ramsden, Zamora and colleagues were able to recover unpublished data from a smaller trial, the Sydney Diet Heart Study, and there they also found more cases of heart disease and death among patients who received a linoleic acid intervention (safflower oil), compared to controls.

Following their recovery of data from the MCE study, the researchers added new data to their existing datasets from the Sydney study and the other three published randomized clinical trials of linoleic acid-based dietary interventions. In a meta-analysis of the combined data, they again found no evidence that these interventions reduced deaths from heart disease or deaths from all causes.

"There were some differences among these studies, but on the whole they didn't really disagree," said Zamora.

Why linoleic acid-containing oils would lower cholesterol but worsen or at least fail to reduce risk is a subject of ongoing research and lively debate. Some studies suggest that these oils can - under certain circumstances - cause inflammation, a known risk factor for disease. There is also some evidence they can promote atherosclerosis when the oils are chemically modified in a process called oxidation.

Explore further: Some 'healthy' vegetable oils may actually increase risk of heart disease

More information: Christopher E Ramsden et al. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73), BMJ (2016). DOI: 10.1136/bmj.i1246 , www.bmj.com/content/353/bmj.i1246

J Lennert Veerman. Dietary fats: a new look at old data challenges established wisdom, BMJ (2016). DOI: 10.1136/bmj.i1512 , www.bmj.com/content/353/bmj.i1512

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humy
5 / 5 (3) Apr 13, 2016
Yet more evidence that neither saturated fat or cholesterol is the cause of heart disease.
And there never was any evidence that it was!
Exactly how much more evidence against this myth is needed before finally people get the message?
marko
5 / 5 (1) Apr 13, 2016
Perhaps somebody should tell the French that too much butter is bad for you.
Jim4321
5 / 5 (3) Apr 13, 2016
The study generalizes from corn oil and corn oil margarine (actually used) to vegetable oil. This seems unwarranted. Given the date of the study, the margarine was almost certainly solid and one must ask if there was an increase in trans fat in the corn oil intervention group.
Anonym
5 / 5 (2) Apr 13, 2016
Next thing ya know, they'll be telling us that some forgotten study from the '70s showed that that marijuana stuff is good for you while that prison stuff is bad for you!
katesisco
1 / 5 (1) Apr 13, 2016
Pick up any good cookbook "from the 60s" and you will find the information that all fats except coconut oil are on the grocery shelf deodorized because they are rancid. Even olive oil is only now being packaged in dark glass or plastic(!) Rancid fats strip B vitamins from the bloodstream and wrecks havoc. All is/was known. Capitalism and profit is all that matters.
katesisco
4 / 5 (1) Apr 13, 2016
Info on consequences of rancid fats. https://nutrition...cid-fat/
schultzy2012
5 / 5 (1) Apr 13, 2016
If they want cause, I can provide them with the direction for further research. First, study the uptake rates for partially hydrogenated oils in relation to non-hydrogenated oils. Then do a cadaver study aimed at the differences in structure between arterial plaques in those whose diets differed in the consumption of saturated animal fats in relation to those whose diets are rich in partially hydrogenated fats. You will find that, even when consumed together, the body will preferentially take up the partially hydrogenated fats over the other. You will also find that arterial plaques formed in people with a preponderance of partially hydrogenated fats in their diet will have plaques of a more more brittle nature, ultimately more prone to scaling and flaking. This is the primary source of the increased incidence of mortality. Brittle plaques flake off and obstruct blood flow and function. Myocardial infarction (MI) or stroke, it's all the same.
MR166
not rated yet Apr 29, 2016
I think that there is a huge problem with the way some "research" is funded. They are paid to produce a given result which may or may not represent the truth. They have killed millions with false studies.

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