Daily calcium intake of 1,000 or 2,000 mg best for rickets

June 27, 2016

(HealthDay)—For children with rickets, radiographic healing is more rapid with 1,000 mg and 2,000 mg daily calcium intake compared with 500 mg, according to a study published online June 17 in the Journal of Bone and Mineral Research.

Tom D. Thacher, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues examined the optimal dose of for treatment of rickets in children. A cohort of 65 Nigerian children with radiographically-confirmed rickets were randomized to daily supplemental calcium intake of 500 mg, 1,000 mg, or 2,000 mg (21, 23, and 21 children, respectively).

The researchers observed improvement in the radiographic severity scores in all three groups, with significantly more rapid rates of in the 1,000 and 2,000 mg supplementation groups versus the 500 mg . There was no difference in the rate of healing between the 1,000 and 2,000 mg groups. A radiographic score of 1.5 or less was achieved by 67, 87, and 67 percent of participants in the 2,000, 1,000, and 500 mg groups, respectively, after 24 weeks (P = 0.21). Similar decreases were seen in all groups in serum alkaline phosphatase and calcium.

"Daily calcium intakes of 1,000 mg or 2,000 mg produced more rapid radiographic healing of than 500 mg, but 2,000 mg did not have greater benefit than 1,000 mg," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

Explore further: Cow's milk allergy in childhood may lead to weaker bones: study

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Calcium and vitamin D help hormones help bones

June 26, 2013

Should women take calcium and vitamin D supplements after menopause for bone health? Recommendations conflict, and opinions are strong. But now, an analysis from the major Women's Health Initiative (WHI) trial throws weight ...

Tasquinimod improves radiographic PFS in mCRPC

June 16, 2016

(HealthDay)—For chemotherapy-naive men with metastatic castration-resistant prostate cancer (mCRPC), tasquinimod is associated with improved radiographic progression-free survival (rPFS), according to a phase III study ...

USPSTF: Vitamin D, calcium supplements don't prevent fx

February 26, 2013

(HealthDay)—For non-institutionalized postmenopausal women, the U.S. Preventive Services Task Force (USPSTF) recommends against daily supplementation with ≤400 IU of vitamin D3 and ≤1,000 mg of calcium for primary prevention ...

Recommended for you


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.