Three-drug tx ups survival in light-chain amyloidosis

Three-drug tx ups survival in light-chain amyloidosis

(HealthDay)—For patients with heart failure due to light-chain amyloidosis (AL), three-drug therapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved survival, according to a study published in the June 28 issue of the Journal of the American College of Cardiology.

In a retrospective study, Brett W. Sperry, M.D., from the Cleveland Clinic Foundation, and colleagues examined the effect of BDex+AA as a first-line treatment strategy in patients with symptomatic from AL cardiac amyloidosis. Data were included for 106 treated patients, 40 of whom received the three-drug regimen and 66 of whom received other regimens. Survival was assessed after adjustment for the for receiving treatment, age, New York Heart Association functional class, and .

The researchers found that mortality was 65, 48, and 76 percent, respectively, overall, in the BDex+AA cohort, and in patients receiving other regimens. After multivariable adjustment, initial treatment with BDex+AA correlated with decreased mortality (hazard ratio, 0.209; P = 0.006). After further adjustment for components of the Mayo Stage the association persisted.

"Use of BDex+AA in the treatment of AL amyloidosis in patients presenting with symptomatic heart failure is associated with improved survival after adjusting for clinical variables," the authors write.

Two authors disclosed financial ties to pharmaceutical companies, including Takeda, the manufacturer of bortezomib.

Explore further

Worse prognosis for heart failure patients with low osmolality

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Copyright © 2016 HealthDay. All rights reserved.

Citation: Three-drug tx ups survival in light-chain amyloidosis (2016, June 21) retrieved 26 January 2021 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments