Metamizole could be alternative to classical NSAIDs

July 14, 2016

(HealthDay)—Metamizole seems to be safer than other nonsteroidal anti-inflammatory drugs (NSAIDs) and causes fewer gastric and duodenal ulcers in postoperative pain management, according to a review published online June 27 in Pain Practice.

Noting that use of metamizole has been discouraged because of the risk for agranulocytosis, Jorieke Konijnenbelt-Peters, M.D., Ph.D., from Canisius Wilhelmina Ziekenhuis in Nijmegen, Netherlands, and colleagues conducted a systematic literature review to examine whether metamizole could be an alternative to classical NSAIDs in postoperative pain management.

The researchers found that there were fewer gastric and duodenal ulcers with metamizole versus other nonselective NSAIDs, with a limited risk of bleeding. It was unknown whether metamizole was safer than a nonselective NSAID together with a . In healthy volunteers, the drug appeared to be safe for , but data were lacking for high-risk patients (such as those with heart or ). The incidence of metamizole-induced agranulocytosis was controversial, but in this selected group of patients, the risk was likely limited to short-term postoperative use.

"Although firm evidence is lacking, metamizole may be safer for the upper intestinal tract and kidneys than other NSAIDs, and could alternatively be used in patients with an increased risk for stomach or renal problems," the authors write. "The risk for metamizole-induced agranulocytosis is judged to be acceptable."

Explore further: Researchers determine the best strategy for preventing ulcers when taking NSAIDs

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Researchers determine the best strategy for preventing ulcers when taking NSAIDs

May 13, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs)—including ibuprofen, diclofenac, naproxen and others—are commonly used pain medications that are generally safe but may increase the risk of developing stomach and intestinal ...

Study examines NSAID use, risk of anastomotic failure following surgery

January 21, 2015
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of anastomotic leak at the surgical junction in patients undergoing nonelective colorectal procedures, according to a report published ...

Ibuprofen doesn't increase bleeding risk after plastic surgery

March 31, 2016
Patients are often instructed not to take ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) before or after surgery because of increased bleeding risk. But available evidence suggests that ibuprofen does not ...

Some painkillers tied to bleeding risk in those with abnormal heartbeat

November 18, 2014
(HealthDay)—People with the abnormal heartbeat known as atrial fibrillation who take common painkillers might significantly increase their risk for bleeding and blood clots, according to a new study.

New study shows increased risk of venous thromboembolism among NSAIDs users

September 24, 2014
A new study published online today in the journal Rheumatology demonstrates that there is a statistically significant increased risk of venous thromboembolism (VTE) – a condition which includes deep vein thrombosis and ...

Common painkillers combined with other drugs may cause high risk of GI bleeding

October 2, 2014
Nonsteroidal anti-inflammatory drugs (NSAIDs)—such as ibuprofen and aspirin—increase one's risk of upper gastrointestinal bleeding. When taken in combination with other drugs, this risk is significantly higher, according ...

Recommended for you

Pain relief at a lower opioid dose

June 25, 2018
A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways—one that has previously been linked to how the brain senses "itch"—may improve pain relief when combined ...

Medical milestone: US OKs marijuana-based drug for seizures

June 25, 2018
U.S. health regulators on Monday approved the first prescription drug made from marijuana, a milestone that could spur more research into a drug that remains illegal under federal law, despite growing legalization for recreational ...

Health insurance plans may be fueling opioid epidemic

June 22, 2018
Health care insurers including Medicare, Medicaid and major private insurers have not done enough to combat the opioid epidemic, suggests a study led by researchers at Johns Hopkins Bloomberg School of Public Health.

Overdose risk quintuples with opioid and benzodiazepine use

June 22, 2018
In the first 90 days of concurrent opioid and benzodiazepine use, the risk of opioid-related overdose increases five-fold compared to opioid-only use among Medicare recipients, according to a new study from the University ...

Discovery opens door for synthetic opioids with less addictive qualities

June 1, 2018
Making opioids from sugar instead of from field grown opium poppies has the potential to solve many of the problems associated with manufacturing strong pain killers.

US doctors prescribing fewer opioid painkillers: report

May 31, 2018
US doctors reduced the number of prescriptions for opioid painkillers last year, continuing a five-year trend, in an effort to reverse a deadly drug abuse epidemic, a report released Thursday said.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.