Antimicrobial resistance to carbapenems increasing

Antimicrobial resistance to carbapenems increasing

(HealthDay)—Antimicrobial resistance to carbapenems has increased, and consumption of antibiotics, especially carbapenems, is associated with antimicrobial resistance of Pseudomonas aeruginosa, according to a study published online Aug. 11 in the Journal of Clinical Pharmacy and Therapeutics.

Snezana Mladenovic-Antic, from the University of Nis in Serbia, and colleagues examined the correlation between antimicrobial usage and of P. aeruginosa over a 10-year period. Antibiotic utilization was recorded, expressed as defined daily doses per 100 bed days.

The researchers identified a significant increasing trend in imipenem and meropenem resistance (both P < 0.05). There was a significant correlation between aminoglycoside consumption and amikacin and gentamicin resistance (both P < 0.01). The correlation between carbapenem consumption and resistance to imipenem in P. aeruginosa was significant (P < 0.01), while there was a trend toward resistance to meropenem (P > 0.05). The correlation between use of all beta-lactam and P. aeruginosa resistance to carbapenems was very good (P < 0.01 for imipenem and P < 0.05 for meropenem).

"Our data demonstrated a significant increase in to carbapenems, significant correlations between the consumption of antibiotics, especially carbapenems and beta-lactams, and rates of antimicrobial resistance of P. aeruginosa to imipenem and meropenem," the authors write.


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