Donor fecal microbiota transplant effective for C. difficile infection

August 24, 2016

(HealthDay)—For patients with recurrent Clostridium difficile infection (CDI), donor fecal microbiota transplantation (FMT) is safe and more efficacious than autologous FMT, according to a study published online Aug. 23 in the Annals of Internal Medicine.

In an effort to examine the efficacy and safety of FMT, Colleen R. Kelly, M.D., from the Warren Alpert Medical School of Brown University in Providence, R.I., and colleagues conducted a involving 46 patients at two with three or more recurrences of CDI. Patients were randomized to FMT with donor stool or patient's own stool administered by colonoscopy.

In intention-to-treat analysis, the researchers found that 90.9 percent of patients in the donor FMT group achieved clinical cure, compared with 62.5 percent in the autologous FMT group (P = 0.042). There was variation by site in resolution after autologous FMT (nine of 10 versus six of 14; P = 0.033). For the nine who developed recurrent CDI after autologous FMT, there were no further episodes of CDI after subsequent donor FMT. No FMT-related serious adverse events were observed. Gut bacterial community diversity and composition were restored by donor FMT to resemble that of healthy donors.

"Donor stool administered via colonoscopy seemed safe and was more efficacious than autologous FMT in preventing further CDI episodes," the authors write.

Explore further: Frozen vs. fresh fecal transplantation for C. diff. infection shows similar effectiveness

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Frozen vs. fresh fecal transplantation for C. diff. infection shows similar effectiveness

January 12, 2016
Among adults with Clostridium difficile infection that is recurrent or not responsive to treatment, the use of frozen compared with fresh fecal microbiota transplantation (FMT) did not result in a significantly lower rate ...

FMT now available in capsule form: could this be the end of antibiotics in C. difficile?

October 6, 2015
A new capsule form of faecal microbiota transplantation (FMT) has raised hopes that this effective treatment for Clostridium difficile (C. difficile) infection and other bowel conditions might soon become mainstream. A recently-reported ...

AGA establishes NIH-funded registry to track fecal microbiota transplants

August 4, 2016
Today, the American Gastroenterological Association (AGA) announced that it has received funding from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) to launch ...

Transplanting healthy stool might be an answer to ulcerative colitis

May 23, 2016
Fecal microbiota transplantation (FMT)—a treatment currently used to address recurring Clostridium difficile infection—is also an effective approach to helping individuals who suffer from ulcerative colitis (UC), according ...

New evidence supports success of fecal transplants in treatment of Clostridium difficile infection

April 9, 2015
Research published in the open access journal Microbiome offers new evidence for the success of fecal microbial transplantation (FMT) in treating severe Clostridium difficile infection (CDI), a growing problem worldwide that ...

Article examines fecal microbiota transplantation

August 22, 2013
Fecal microbiota transplantation (FMT) has emerged as a highly effective treatment for recurrent Clostridium difficile (C. difficile) infection, with very early experience suggesting that it may also play a role in treating ...

Recommended for you

First proof a synthesized antibiotic is capable of treating superbugs

March 23, 2018
A "game changing" new antibiotic which is capable of killing superbugs has been successfully synthesised and used to treat an infection for the first time—and could lead to the first new class of antibiotic drug in 30 years.

Scientists identify potential drug target in blood-feeding hookworms

March 22, 2018
In hookworms that infect and feed on the blood of mice, scientists have discovered a key step in blood digestion that can be targeted to disrupt the parasite's development and survival. These findings, published in PLOS Pathogens ...

Global burden of low back pain—a consequence of negligence and misinformation

March 21, 2018
A series of groundbreaking papers from Australian and international researchers in The Lancet, published today (22/3) warns that low back pain is a major health burden globally - across developed and developing nations - ...

Microscopic 'shuttles' transport enzyme from cells to trigger onset of kidney disease

March 21, 2018
A new study involving the University of Sheffield has identified a key culprit in the onset of kidney disease in a major marker for kidney disease development.

Metabolite therapy proves effective in treating C. difficile in mice

March 20, 2018
A team of UCLA researchers found that a metabolite therapy was effective in mice for treating a serious infection of the colon known as Clostridium difficile infection, or C. difficile.

Study of COPD patients has created a 'looking glass' into genome of pathogen

March 19, 2018
Decades of work on chronic obstructive pulmonary disease (COPD) at the University at Buffalo and the Veterans Affairs Western New York Healthcare System have yielded extraordinary information about the pathogen that does ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.