Patient-level model predicts in-hospital mortality in acute MI

August 4, 2016

(HealthDay)—A parsimonious patient-level clinical risk model can predict in-hospital mortality for patients with acute myocardial infarction, according to a study published in the Aug. 9 issue of the Journal of the American College of Cardiology.

Robert L. McNamara, M.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues developed and validated a parsimonious patient-level clinical risk model of in-hospital mortality for patients with . The population of 243,440 patients from 655 hospitals was divided into a 60 percent sample for derivation of the model and a 40 percent sample for validation of the model.

The researchers found that in-hospital mortality was 4.6 percent. Independent associations for in-hospital mortality were seen for age, heart rate, , presentation after , presentation in cardiogenic shock, presentation in heart failure, presentation with ST-segment elevation myocardial infarction (STEMI), creatinine clearance, and troponin ratio. The C-statistic for the model was 0.88, with good calibration. In subgroups based on age, sex, race, transfer status, and presence of diabetes mellitus, renal dysfunction, cardiac arrest, cardiogenic shock, and STEMI, the model performed well. Across risk groups, the observed mortality rates varied substantially, ranging from 0.4 to 49.5 percent in the lowest and highest risk groups.

"This parsimonious risk model for in-hospital mortality is a valid instrument for risk adjustment and in contemporary patients with acute myocardial infarction," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Explore further: Diabetes confers worse prognosis for patients with ACS

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Diabetes confers worse prognosis for patients with ACS

July 20, 2016
(HealthDay)—For patients with acute coronary syndromes (ACS), diabetes confers a worse prognosis, according to a study published in the Aug. 1 issue of The American Journal of Cardiology.

One in four patients develop heart failure within four years of first heart attack

May 24, 2016
One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25 000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure ...

Post-op myocardial necrosis common after orthopedic sx

June 3, 2015
(HealthDay)—Myocardial necrosis is common after orthopedic surgery and is associated with increased risk of long-term mortality, according to a study published in the June 15 issue of The American Journal of Cardiology.

Kidney injury not uncommon after cardiovascular intervention

January 22, 2014
(HealthDay)—Acute kidney injury (AKI) is seen in about 7 percent of patients undergoing percutaneous coronary intervention (PCI) and is associated with significant in-hospital mortality, according to research published ...

Ambulance use with MI tied to higher mortality

November 5, 2014
(HealthDay)—Using an ambulance for hospital transport of patients with ST-segment elevation myocardial infarction (MI) is associated with higher mortality, according to a study published in the Nov. 1 issue of The American ...

Mortality up with no revascularization in STEMI

June 25, 2016
(HealthDay)—Mortality is increased for patients with non-ST-segment elevation myocardial infarction (NSTEMI) who do not undergo coronary revascularization, according to a study published in the July 1 issue of The American ...

Recommended for you

Biomechanical mapping method aids development of therapies for damaged heart tissue

January 23, 2018
Researchers have developed a new way to capture the detailed biomechanical properties of heart tissue. The high-resolution optical technique fills an important technology gap necessary to develop and test therapies that might ...

Researchers borrow from AIDS playbook to tackle rheumatic heart disease

January 22, 2018
Billions of US taxpayer dollars have been invested in Africa over the past 15 years to improve care for millions suffering from the HIV/AIDS epidemic; yet health systems on the continent continue to struggle. What if the ...

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.