Metformin alters gut microbiota composition in diabetes (Update)

Metformin alters gut microbiota composition in diabetes

(HealthDay)—Metformin seems to alter gut microbiota composition, according to a study published online Nov. 14 in Diabetes Care.

Jacobo de la Cuesta-Zuluaga, from the Vidarium-Nutrition Health and Wellness Research Center in Medellin, Colombia, and colleagues examined the correlation between type 2 diabetes, , and among Colombian adults. Analyses focused on 28 diagnosed with diabetes (14 taking metformin) and 84 sex-, age-, and body mass index-matched participants without diabetes. Demographic information, anthropometry, and blood biochemical parameters were measured, and fecal samples were collected. The composition and structure of the gut microbiota was analyzed using 16S rRNA gene sequencing.

The researchers observed a correlation between diabetes and gut microbiota, which was modified by use of metformin. Participants with diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, known for mucin degradation, and several gut microbiota known for production of short-chain fatty acids (SCFAs), compared to participants without diabetes. Participants with diabetes not taking metformin had higher relative abundance of Clostridiaceae 02d06 and a distinct operational taxonomic unit of Prevotella, as well as lower abundance of Enterococcus casseliflavus, compared to those without .

"Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota," the authors write. "Future studies are needed to determine if these shifts mediate metformin's glycemic and anti-inflammatory properties."

Several authors disclosed financial ties to the nutrition industry.


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Nov 19, 2016
Huh! So what is the end-line!?! Does that result in a good or bad conclusion??? Not being a scientist nor a doctor, I am at a loss in trying to understand this article. Is it a good thing, or a bad thing, to have more, or less, gut microbiota!?! I do not think I would like to 'search' all those many 'scientific' terms in this article, as I would probably just wind up with more scientific jargon. I can not say I am confused by all this, but just totally in the dark with this article!!! Are they trying to say I should cut down on my Metformin dosage, or even stop taking it, or should I rush to my doctor on Monday and ask to have my Metformin dosage doubled or tripled. For the average reader, this article said a lot - of meaningless babble; perhaps when 'future studies' are performed they might make sense to the 'average' person. Typical of 'scientific' studies - 'cannot compute - more data needed'!!! From bewildered gwetoyking.

Nov 20, 2016
Metformin has been shown to extend the lives of animals and is under research as a human life extension drug. If that's true, then pretty much everything it does is good news


Nov 20, 2016
Hi, I'm diabetic as well. I was wondering if u could tell what diet u used to bring your blood sugar that low! thx

Nov 20, 2016
me 2

Nov 20, 2016
Always beware of quick fix schemes such as the one above. You will wind up spending money and then having to get yourself back on track with your medications. Snake Oil cures are just that!

Nov 21, 2016
thx for the advise, t thought so

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