Scripps first in West to treat heart attack with new supersaturated oxygen therapy

December 28, 2016, Scripps Health
A Scripps researcher is using the TherOx system to test the effectiveness of supersaturated oxygen therapy on heart attack patients. Credit: TherOx Inc.

A physician at Scripps Health's Prebys Cardiovascular Institute has become the first in the Western United States to treat heart attack patients with a new supersaturated oxygen (SSO2) system in an attempt to reduce permanent damage to their heart muscle.

The recent treatments of two San Diego men were part of an ongoing clinical trial examining the effectiveness of the experimental SSO2 system and technique in combination with angioplasty, stenting and medication. Scripps is the only site in California participating in the nationwide study called IC-HOT (Evaluation of Intracoronary Hyperoxemic Oxygen Therapy).

"A heart attack is like a house fire, the longer it takes to put it out, the more structural damage that is done," said John C. Harrington, M.D., the interventional cardiologist who is leading the study at Scripps. "By infusing higher concentrations of oxygen into the artery responsible for the heart attack, we can decrease the size of the area of that is damaged because it is deprived of oxygen."

Every year nearly 1 million people in the United States have a heart attack, typically caused when the blood flow carrying oxygen to the heart is reduced or blocked. Although the standard for heart attack care is angioplasty and stenting, for many patients those treatments aren't enough to salvage dead or damaged heart tissue that was starved of oxygen.

During SSO2 therapy developed by the Irvine, Calif., biotechnology company TherOx Inc., saline is drawn into a chamber in a disposable cartridge inserted into the treatment system. Supersaturated oxygen is sprayed into a second chamber and mixed with the saline. The patient's blood is circulated through a third chamber where it mixes with the SSO2 saline. The blood-oxygen-saline solution is then directed by catheter into the patient's coronary artery where it infuses the capillary bed and surrounding heart tissue. The procedure takes about one hour.

The IC-HOT study seeks to enroll 100 patients who suffer their first heart attack and receive SSO2 treatment within six hours of first experiencing symptoms. The study's primary aim is to validate the safety and effectiveness of the therapy system. Enrollment is expected to be completed by February 2017.

In a previous trial of an earlier generation of the TherOx system which didn't involve Scripps, experienced a median reduction of 26 percent in the size of the damaged area of their compared to angioplasty and stenting alone.

The treatment of heart attacks has advanced greatly over the past few decades, leading to improvements in mortality rates and decreased hospital stays. Minimally invasive catheter procedures, which deliver stents, angioplasty balloons and other treatments to the heart through veins and arteries, have greatly reduced the need for open heart surgeries.

Still, more needs to be done.

Patients with nearly identical characteristics - age, risk factors and cardiovascular muscle damage from the same type of —can receive the same treatment but experience very different outcomes.

"One patient may have preserved heart function while the other may have a large area of death," Dr. Harrington said. "Clearly there are additional factors that need to be explored to reduce .

"The hope is that people receiving SSO2 treatment will leave the hospital with a less damaged ," he said.

Explore further: Extreme makeover of the heart: Matrix therapy is first FDA-approved procedure of its kind

Related Stories

Extreme makeover of the heart: Matrix therapy is first FDA-approved procedure of its kind

September 17, 2015
A cardiovascular team at University of Utah Hospital has successfully performed a first-in-the-world heart procedure on a 72-year-old attorney after suffering a large heart attack. Amit N. Patel, M.D. M.S., director of clinical ...

New research offers reassurance over multiple artery procedures for heart attack victims

December 17, 2015
A new study has examined the effects on the heart of treating multiple narrowed arteries - rather than just one – at the time of a heart attack.

The Miriam Hospital recruiting for clinical trial of device to treat heart failure

October 31, 2015
The Miriam Hospital is actively recruiting local participants for a U.S. clinical trial of the Parachute device for treating heart failure. The study is focused on determining if the new minimally invasive catheter-based ...

Resuming exercise soon after heart attack can improve heart recovery

August 4, 2015
Exercise promotes heart health. However, many lifestyle factors cause heart disease, and regular activity may not be enough to prevent heart attacks. A new study in the American Journal of Physiology–Heart and Circulatory ...

Deferred stenting shows no clinical benefit

April 4, 2016
Delayed or deferred stent implantation in patients experiencing the deadliest form of heart attack—ST-segment elevation myocardial infarction (STEMI)—failed to reduce death from any cause, hospitalization for heart failure, ...

Recommended for you

No sweat required: Team finds hypertension treatment that mimics effect of exercise

October 16, 2018
Couch potatoes rejoice—there might be a way to get the blood pressure lowering benefits of exercise in pill form.

New model suggests cuffless, non-invasive blood pressure monitoring possible using pulse waves

October 16, 2018
A large team of researchers from several institutions in China and the U.S. has developed a model that suggests it should be possible to create a cuffless, non-invasive blood pressure monitor based on measuring pulse waves. ...

Why heart contractions are weaker in those with hypertrophic cardiomyopathy

October 16, 2018
When a young athlete suddenly dies of a heart attack, chances are high that they suffer from familial hypertrophic cardiomyopathy (HCM). Itis the most common genetic heart disease in the US and affects an estimated 1 in 500 ...

Novel genetic study sheds new light on risk of heart attack

October 12, 2018
Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

Researchers say ritual for orthodox Jewish men may offer heart benefits

October 11, 2018
A pilot study led by researchers at the University of Cincinnati (UC) College of Medicine suggests Jewish men who practice wearing tefillin, which involves the tight wrapping of an arm with leather banding as part of daily ...

Markers of dairy fat consumption linked to lower risk of type two diabetes

October 10, 2018
Higher levels of biomarkers of dairy fat consumption are associated with a lower risk of developing type 2 diabetes, according to new research published today in PLOS Medicine. The study, in more than 60,000 adults, was undertaken ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.