Study shows adipose stem cells may be the cell of choice for therapeutic applications

February 24, 2017

An international team of researchers, funded by Morris Animal Foundation, has shown that adipose (fat) stem cells might be the preferred stem cell type for use in canine therapeutic applications, including orthopedic diseases and injury.

Researchers at the University of Guelph, University of Western Ontario and Aarhus University, Denmark, ran a battery of tests comparing the physiology characteristics of stem cells derived from adipose tissue versus bone marrow. They found that stem cells from both sources had similar functional properties, including tissue generation and immunomodulating capabilities (ability to adjust immune response), but adipose stem cells grow at a faster rate than bone marrow stem cells. Harvesting adipose stem cells also is less invasive than harvesting bone marrow. The study recently was published in PLoS ONE, an online scientific journal.

In the last decade, the use of stem cell therapy in animals and humans has dramatically increased. In dogs, is used in the treatment of a variety of orthopedic diseases and injuries. Stem cells are harvested from either fat tissue or , purified and grown in culture, then placed back in the patient.

Given the ease of harvesting, has become the site of most stem cell collections in canine patients. But questions persisted regarding the differences between these two sources of stem cells, and which is better suited to therapeutic applications.

"Faster proliferation along with the potential for a less invasive method of their procurement makes them (adipose stem cells) the preferred source for canine mesenchymal ," concluded the research team.

Explore further: Stem cell therapy trial at Sanford first of its kind in US for shoulder injuries

More information: Keith A. Russell et al, Characterization and Immunomodulatory Effects of Canine Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stromal Cells, PLOS ONE (2016). DOI: 10.1371/journal.pone.0167442

Related Stories

Stem cell therapy trial at Sanford first of its kind in US for shoulder injuries

January 4, 2017
The first FDA-approved clinical trial of its kind in the United States using a person's own fat-derived adult stem cells to treat shoulder injuries is available at Sanford Health.

Cancer stem cells in 'robbers cave' may explain poor prognosis for obese patients

July 20, 2016
Across many cancer types, obese patients fare worse than leaner patients. Now a University of Colorado Cancer Center study published in the journal Cell Stem Cell offers a compelling hypothesis why: researchers found that ...

Stem cells aid recovery from stroke

January 27, 2013
Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain ...

Watching stem cells change provides clues to fighting osteoporosis in older women

October 5, 2016
For years, scientists have studied how stem cells might be used to treat many diseases, including osteoporosis. One consistent challenge has been observing and monitoring the process through which stem cells transform. Now, ...

Recommended for you

Drug found that induces apoptosis in myofibroblasts reducing fibrosis in scleroderma

December 15, 2017
(Medical Xpress)—An international team of researchers has found that the drug navitoclax can induce apoptosis (self-destruction) in myofibroblasts in mice, reducing the spread of fibrosis in scleroderma. In their paper ...

How defeating THOR could bring a hammer down on cancer

December 14, 2017
It turns out Thor, the Norse god of thunder and the Marvel superhero, has special powers when it comes to cancer too.

Researchers track muscle stem cell dynamics in response to injury and aging

December 14, 2017
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) describes the biology behind why muscle stem cells respond differently to aging or injury. The findings, published in Cell Stem Cell, ...

'Human chronobiome' study informs timing of drug delivery, precision medicine approaches

December 13, 2017
Symptoms and efficacy of medications—and indeed, many aspects of the human body itself—vary by time of day. Physicians tell patients to take their statins at bedtime because the related liver enzymes are more active during ...

Study confirms link between the number of older brothers and increased odds of being homosexual

December 12, 2017
Groundbreaking research led by a team from Brock University has further confirmed that sexual orientation for men is likely determined in the womb.

Potassium is critical to circadian rhythms in human red blood cells

December 12, 2017
An innovative new study from the University of Surrey and Cambridge's MRC Laboratory of Molecular Biology, published in the prestigious journal Nature Communications, has uncovered the secrets of the circadian rhythms in ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.