New study compares bone-inducing properties of 3-D-printed mineralized scaffolds

February 13, 2017
Credit: Mary Ann Liebert, Inc., publishers

A new study of bone formation from stem cells seeded on 3D-printed bioactive scaffolds combined with different mineral additives showed that some of the scaffold mineral composites induced bone-forming activity better than others. The properties and potential to use these bioactive scaffolds in bone regeneration applications are discussed in an article published in Tissue Engineering, Part A.

Ethan Nyberg, Alexandra Rindone, Amir Dorafshar, and Warren Grayson, Johns Hopkins University School of Medicine and Johns Hopkins University, Baltimore, MD, examined the print quality of several different composite 3D-printed bone scaffolds. In the article entitled "Comparison of 3D-Printed Poly-ε-caprolactone Scaffolds Functionalized with Tricalcium Phosphate, Hydroxyapatite, Bio-Oss, or Decellularized Bone Matrix," they report on the mechanical and structural properties of the various porous scaffolds, to which they added adipose-derived . The researchers then assessed the bone-inducing properties of each hybrid scaffold, measuring osteoblast formation, calcium content, and collagen expression.

"In the continuum of materials used to regenerate bone, harnessing the power of both biomaterial scaffolds and known crystalline bone regeneration materials provides maximal flexibility in therapy," says Tissue Engineering Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.

Explore further: Promising results using silver-releasing scaffolds in MRSA infection of bone

More information: Ethan Nyberg et al, Comparison of 3D-Printed Poly-ɛ-Caprolactone Scaffolds Functionalized with Tricalcium Phosphate, Hydroxyapatite, Bio-Oss, or Decellularized Bone Matrix, Tissue Engineering Part A (2017). DOI: 10.1089/ten.tea.2016.0418

Related Stories

Nanofibres developed for healing bone fractures

January 18, 2017

In the future, it may be possible to use nanofibres to improve the attachment of bone implants, or the fibres may be used directly to scaffold bone regeneration. This would aid the healing of fractures and may enable the ...

Recommended for you

Bioelectricity new weapon to fight dangerous infection

May 26, 2017

Changing the natural electrical signaling that exists in cells outside the nervous system can improve resistance to life-threatening bacterial infections, according to new research from Tufts University biologists. The researchers ...

New hair growth mechanism discovered

May 25, 2017

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced "tee-regs"), a type of immune cell generally associated with controlling inflammation, directly trigger stem ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.