High CVD risk in patients with head, neck squamous cell cancer

February 2, 2017

(HealthDay)—Twenty-three percent of patients with head and neck squamous cell carcinoma (HNSCC) have cardiovascular disease (CVD) at diagnosis, and 24 percent have uncontrolled blood pressure, according to research published online Dec. 29 in Head & Neck.

Christian C. Okoye, M.D., from Case Western Reserve University in Cleveland, and colleagues retrospectively reviewed patients with HNSCC who underwent definitive or adjuvant (chemo)radiation between 2011 and 2013. The authors calculated the 10-year risk estimates for a event according to the Framingham Risk Score (FRS).

One hundred fifteen patients with mainly stage III/IV HNSCC were followed up for a median of two years. The researchers found that 23 percent of patients had CVD at diagnosis. Patients with laryngeal cancer had higher FRS than those with cancer at other sites (20.5 versus 14.4 percent). At diagnosis, 24 percent of all patients had uncontrolled blood pressure. Forty-one and 30 percent of patients with CVD were not taking antiplatelet or statin therapy, respectively. Indications for initiating were seen for 34 percent of with CVD.

"Patients with HNSCC have a high baseline CVD risk and many do not receive optimal preventive care," the authors write.

Explore further: Periodontitis linked to HPV-positive head, neck tumors

More information: Full Text (subscription or payment may be required)

Related Stories

Periodontitis linked to HPV-positive head, neck tumors

June 20, 2012
(HealthDay) -- For patients with head and neck squamous cell carcinoma (HNSCC) there is an increased risk of human papillomavirus (HPV)-positive tumors among those with a history of periodontitis, according to a study published ...

No specific findings to ID recurrence in head and neck CA

September 26, 2015
(HealthDay)—For patients treated for head and neck squamous cell carcinoma (HNSCC), no definite index of symptoms or signs indicates local recurrence or second primary malignancy, according to a study published online Sept. ...

Type of treatment impacts recurrence in laryngeal SCC

December 14, 2016
(HealthDay)—For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online Nov. 30 in ...

Statins reduce risk of mortality in multiple myeloma

October 4, 2016
(HealthDay)—Statin therapy is associated with reduced risk of all-cause and multiple myeloma (MM)-specific mortality, according to a study published online Sept. 19 in the Journal of Clinical Oncology.

Chemoradiation may increase survival for a subset of elderly head and neck cancer patients

February 18, 2016
The addition of chemotherapy (CT) to radiation therapy (RT) improves survival rates among a subset of elderly head and neck cancer patients, specifically those ages 71 to 79 with low comorbidity scores and advanced disease ...

Chemotherapy before chemoradiation shows no survival advantage in head and neck cancer

February 18, 2016
Head and neck cancer patients who receive chemotherapy prior to radiation therapy (induction chemotherapy or IC) rather than the standard treatment that combines chemotherapy with radiation (chemoradiation or CRT) show no ...

Recommended for you

Targeting the engine room of the cancer cell

June 18, 2018
Researchers at Columbia University Irving Medical Center (CUIMC) have developed a highly innovative computational framework that can support personalized cancer treatment by matching individual tumors with the drugs or drug ...

Researchers create novel combination as potential therapy for high-risk neuroblastoma

June 18, 2018
Researchers at VCU Massey Cancer Center in Richmond, Virginia, have identified a promising target to reverse the development of high-risk neuroblastoma and potentially inform the creation of novel combination therapies for ...

Study suggests well-known growth suppressor actually fuels lethal brain cancers

June 18, 2018
Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. But they also say the current lack of a drug that hits the molecular target keeps it ...

Genomics offers new treatment options for infants with range of soft tissue tumors

June 18, 2018
The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators. Whole genome sequencing of tumours revealed ...

Standard myelofibrosis drug can awaken 'dormant' lymphoma

June 18, 2018
Most patients with myelofibrosis, a rare chronic disorder of the haematopoietic cells of the bone marrow, benefit from drugs from the JAK2 inhibitor class: symptoms are relieved, survival extended and general quality-of-life ...

Breast cancer researcher warns against online genetic tests

June 18, 2018
We have never been so fascinated by the secrets inside our cells.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.