Researchers urge radiotherapy for all patients with bone mets

February 13, 2017

(HealthDay)—For patients with bone metastases, those responding to radiotherapy experience greater pain reduction and better quality of life (QOL) at day 10 after radiotherapy, according to a study published online Feb. 9 in JAMA Oncology.

Rachel McDonald, M.D., from Sunnybrook Health Sciences Centre in Toronto, and colleagues used a bone metastases-specific QOL tool to examine QOL at days 10 and 42 after among 298 patients from 23 Canadian centers.

The researchers found that 40.9 and 38.9 percent of patients responded to radiotherapy at day 10 and 42, respectively. Compared with non-responders, patients with a had a greater reduction in (mean reduction, 17.0 versus 1.8; P = 0.002) and pain characteristics (mean reduction, 12.8 versus 1.1; P = 0.002) at day 10; they also had greater improvements in functional interference (mean increase, 11.6 versus 3.6; P = 0.01) and psychosocial aspects (mean, 1.2-point increase in responders versus 2.2-point decrease in non-responders; P = 0.04). Compared with non-responders, responders had significantly greater improvements in physical, emotional, and global domains of the European Organisation for Research and Treatment of Cancer Quality of Life Core 15 Palliative when comparing changes in QOL from baseline to day 42 (all P < 0.001).

"A single 8-Gy radiotherapy dose for bone metastases should be offered to all , even those with poor survival," the authors write.

Explore further: Intravenous lidocaine offers alternative for ICU patients' pain

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Intravenous lidocaine offers alternative for ICU patients' pain

February 9, 2017
(HealthDay)—Intravenous lidocaine (IVLI) seems safe for reducing pain among patients in the intensive care unit (ICU) with varying degrees of organ dysfunction, according to research published online Feb. 7 in the Journal ...

Pregabalin significantly improves neuropathic pain

September 9, 2016
(HealthDay)—Pregabalin significantly improves neuropathic pain, irrespective of the time since pain onset, according to a study published online Sept. 2 in Pain Practice.

Rifaximin effective for repeat treatment of IBS with diarrhea

December 27, 2016
(HealthDay)—Repeat treatment with the nonsystemic antibiotic rifaximin is effective in patients with relapsing symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D), according to a study published in the December ...

Palliative radiotherapy for bone metastases in elderly patients improves quality of life

April 22, 2013
Giving palliative radiotherapy to elderly patients with painful bone metastases can significantly improve their quality of life, a Dutch researcher told the 2nd Forum of the European Society for Radiotherapy and Oncology ...

Bone-strengthening drug gives pain relief in prostate cancer bone metastases

September 25, 2011
Stockholm, Sweden: Many prostate cancer patients develop bone metastases, and controlling the pain these cause can be difficult. Now the first large randomised Phase III trial of a bisphosphonate drug in these patients has ...

Decision regret uncommon after radical prostatectomy, IMRT

August 22, 2016
(HealthDay)—For patients with prostate cancer treated with radical prostatectomy (RP) and post-prostatectomy image-guided intensity-modulated radiotherapy (IG-IMRT), decision regret (DR) is uncommon and occurs more often ...

Recommended for you

Study tracks evolutionary transition to destructive cancer

February 23, 2018
Evolution describes how all living forms cope with challenges in their environment, as they struggle to persevere against formidable odds. Mutation and selective pressure—cornerstones of Darwin's theory—are the means ...

Putting black skin cancer to sleep—for good

February 22, 2018
An international research team has succeeded in stopping the growth of malignant melanoma by reactivating a protective mechanism that prevents tumor cells from dividing. The team used chemical agents to block the enzymes ...

Cancer risk associated with key epigenetic changes occurring through normal aging process

February 22, 2018
Some scientists have hypothesized that tumor-promoting changes in cells during cancer development—particularly an epigenetic change involving DNA methylation—arise from rogue cells escaping a natural cell deterioration ...

NEJM reports positive results for larotrectinib against TRK-fusion cancer

February 22, 2018
In 2013, the labs of University of Colorado Cancer Center investigator Robert C. Doebele, MD, PhD, and Dana-Farber Cancer Institute investigator Pasi A. Jänne, MD, PhD reported in Nature Medicine the presence of TRK gene ...

New therapeutic gel shows promise against cancerous tumors

February 21, 2018
Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results ...

Five novel genetic changes linked to pancreatic cancer risk

February 21, 2018
In what is believed to be the largest pancreatic cancer genome-wide association study to date, researchers at the Johns Hopkins Kimmel Cancer Center and the National Cancer Institute, and collaborators from over 80 other ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.