Allen Cell Types Database updated with new data and models

March 17, 2017
Users of the Allen Cell Types Database can explore the morphological and electrophysiological properties of individual neurons from the mouse visual cortex. Credit: Allen Institute

The Allen Institute for Brain Science has released additional data and computer models of cell activity for inclusion in the Allen Cell Types Database: a publicly available tool for researchers to explore and understand the building blocks of the brain.

"Comprehensive coverage of hundreds to thousands of cells will be crucial for scientists who want to explore the diversity of in the , and provides a base from which we can parse cells into meaningful types," says Lydia Ng, Ph.D., Senior Director of Technology at the Allen Institute for Brain Science. "This release is one more step in building a fundamental framework to help make advancements in neuroscience."

Models serve as a critical link between observed data and theories about how cells work, enabling scientists to understand the mechanisms that give rise to neuron function. Two types of models have been added and updated as part of this release. The first set are models that reduce the complexity of neurons and use cell measurements to "predict" the activity and function of those cells, which are now available for 633 neurons in the database.

Additionally, more sophisticated neuronal models based on cell shape, morphology and subcellular components are now available for hundreds of neurons via an interactive web browser.

The Allen Cell Types Database contains detailed descriptive features gathered from in the mouse brain, including location, electrical activity and shape. For this release, electrophysiological recordings from an additional 130 cells from the cortex have been added to the database.

The Allen Cell Types Database (celltypes.brain-map.org) is a fundamental resource of the Allen Institute's ten-year plan to understand how activity in the brain leads to perception, decision-making and action. Understanding —the brain's building blocks—is critical to making sense of both how the healthy brain functions and what goes wrong in diseases such as autism, Alzheimer's and Parkinson's.

Additional updates to Allen Brain Atlas resources are planned for June and October of 2017.

Explore further: Allen Cell types database launched

More information: celltypes.brain-map.org/

Related Stories

Allen Cell types database launched

May 14, 2015
The Allen Institute for Brain Science announced today that it is taking the first major scientific step to create a searchable standards database for the brain with the launch of the Allen Cell Types Database. This first ...

Team announces mapping of the mouse cortex in 3-D

October 27, 2016
The Allen Institute for Brain Science has completed the three-dimensional mapping of the mouse cortex as part of the Allen Mouse Common Coordinate Framework (CCF): a standardized spatial coordinate system for comparing many ...

Using genes to understand the brain's building blocks

January 4, 2016
Understanding the cellular building blocks of the brain, including the number and diversity of cell types, is a fundamental step toward understanding brain function. Researchers at the Allen Institute for Brain Science have ...

Allen Brain Observatory launched

July 13, 2016
The Allen Institute for Brain Science today announced the release of the Allen Brain Observatory: a highly standardized survey of cellular-level activity in the mouse visual system. This dynamic tool empowers scientists to ...

New, highly realistic computer models of neurons

March 3, 2016
The Allen Institute for Brain Science and the Blue Brain Project are deepening their collaboration. Today, the US-based Allen Institute is releasing a set of 40 computer models of neurons from the mouse visual cortex, created ...

Allen Institute for Brain Science announces new data release on Allen Brain Atlas resources

December 20, 2013
The Allen Institute for Brain Science recently announced major updates to the online public resources available through the Allen Brain Atlas data portal. The updates include feature enhancements and data additions to four ...

Recommended for you

The brain at work: Spotting half-hidden objects

September 19, 2017
How does a driver's brain realize that a stop sign is behind a bush when only a red edge is showing? Or how can a monkey suspect that the yellow sliver in the leaves is a round piece of fruit?

Epileptic seizures show long-distance effects

September 19, 2017
The area in which an epileptic seizure starts in the brain, may be small but it reaches other parts of the brain at distances of over ten centimeters. That distant activity, in turn, influences the epileptic core, according ...

Study uncovers markers for severe form of multiple sclerosis

September 18, 2017
Scientists have uncovered two closely related cytokines—molecules involved in cell communication and movement—that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease. ...

Genetically altered mice bear some hallmarks of human bipolar behavior

September 18, 2017
Johns Hopkins researchers report they have genetically engineered mice that display many of the behavioral hallmarks of human bipolar disorder, and that the abnormal behaviors the rodents show can be reversed using well-established ...

Brain halves increase communication to compensate for aging, study finds

September 15, 2017
Increased communication between distant brain regions helps older adults compensate for the negative aspects of aging, reports a new study published this week in Human Brain Mapping.

Memory decline after head injury may be prevented by slowing brain cell growth

September 15, 2017
The excessive burst of new brain cells after a traumatic head injury that scientists have traditionally believed helped in recovery could instead lead to epileptic seizures and long-term cognitive decline, according to a ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.