Allen Cell Types Database updated with new data and models

March 17, 2017, Allen Institute for Brain Science
Users of the Allen Cell Types Database can explore the morphological and electrophysiological properties of individual neurons from the mouse visual cortex. Credit: Allen Institute

The Allen Institute for Brain Science has released additional data and computer models of cell activity for inclusion in the Allen Cell Types Database: a publicly available tool for researchers to explore and understand the building blocks of the brain.

"Comprehensive coverage of hundreds to thousands of cells will be crucial for scientists who want to explore the diversity of in the , and provides a base from which we can parse cells into meaningful types," says Lydia Ng, Ph.D., Senior Director of Technology at the Allen Institute for Brain Science. "This release is one more step in building a fundamental framework to help make advancements in neuroscience."

Models serve as a critical link between observed data and theories about how cells work, enabling scientists to understand the mechanisms that give rise to neuron function. Two types of models have been added and updated as part of this release. The first set are models that reduce the complexity of neurons and use cell measurements to "predict" the activity and function of those cells, which are now available for 633 neurons in the database.

Additionally, more sophisticated neuronal models based on cell shape, morphology and subcellular components are now available for hundreds of neurons via an interactive web browser.

The Allen Cell Types Database contains detailed descriptive features gathered from in the mouse brain, including location, electrical activity and shape. For this release, electrophysiological recordings from an additional 130 cells from the cortex have been added to the database.

The Allen Cell Types Database (celltypes.brain-map.org) is a fundamental resource of the Allen Institute's ten-year plan to understand how activity in the brain leads to perception, decision-making and action. Understanding —the brain's building blocks—is critical to making sense of both how the healthy brain functions and what goes wrong in diseases such as autism, Alzheimer's and Parkinson's.

Additional updates to Allen Brain Atlas resources are planned for June and October of 2017.

Explore further: Allen Cell types database launched

More information: celltypes.brain-map.org/

Related Stories

Allen Cell types database launched

May 14, 2015
The Allen Institute for Brain Science announced today that it is taking the first major scientific step to create a searchable standards database for the brain with the launch of the Allen Cell Types Database. This first ...

Team announces mapping of the mouse cortex in 3-D

October 27, 2016
The Allen Institute for Brain Science has completed the three-dimensional mapping of the mouse cortex as part of the Allen Mouse Common Coordinate Framework (CCF): a standardized spatial coordinate system for comparing many ...

Using genes to understand the brain's building blocks

January 4, 2016
Understanding the cellular building blocks of the brain, including the number and diversity of cell types, is a fundamental step toward understanding brain function. Researchers at the Allen Institute for Brain Science have ...

Allen Brain Observatory launched

July 13, 2016
The Allen Institute for Brain Science today announced the release of the Allen Brain Observatory: a highly standardized survey of cellular-level activity in the mouse visual system. This dynamic tool empowers scientists to ...

New, highly realistic computer models of neurons

March 3, 2016
The Allen Institute for Brain Science and the Blue Brain Project are deepening their collaboration. Today, the US-based Allen Institute is releasing a set of 40 computer models of neurons from the mouse visual cortex, created ...

Allen Institute for Brain Science announces new data release on Allen Brain Atlas resources

December 20, 2013
The Allen Institute for Brain Science recently announced major updates to the online public resources available through the Allen Brain Atlas data portal. The updates include feature enhancements and data additions to four ...

Recommended for you

Perinatal hypoxia associated with long-term cerebellar learning deficits and Purkinje cell misfiring

August 18, 2018
Oxygen deprivation associated with preterm birth leaves telltale signs on the brains of newborns in the form of alterations to cerebellar white matter at the cellular and the physiological levels. Now, an experimental model ...

CRISPR technology targets mood-boosting receptors in brain

August 17, 2018
An estimated 13 percent of Americans take antidepressant drugs for depression, anxiety, chronic pain or sleep problems. For the 14 million Americans who have clinical depression, roughly one third don't find relief with antidepressants.

People are more honest when using a foreign tongue, research finds

August 17, 2018
New UChicago-led research suggests that someone who speaks in a foreign language is probably more credible than the average native speaker.

Critical role of DHA on foetal brain development revealed

August 17, 2018
Duke-NUS researchers have found evidence that a natural form of Docosahexaenoic Acid (DHA) made by the liver called Lyso-Phosphatidyl-Choline (LPC-DHA), is critical for normal foetal and infant brain development, and that ...

Automated detection of focal epileptic seizures in a sentinel area of the human brain

August 17, 2018
Patients with focal epilepsy that does not respond to medications badly need alternative treatments.

Brain response study upends thinking about why practice speeds up motor reaction times

August 16, 2018
Researchers in the Department of Physical Medicine and Rehabilitation at Johns Hopkins Medicine report that a computerized study of 36 healthy adult volunteers asked to repeat the same movement over and over became significantly ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.