Serum periostin IDs comorbid chronic rhinosinusitis in asthma

March 21, 2017

(HealthDay)—For patients with asthma, serum periostin is useful for detecting chronic rhinosinusitis with nasal polyps, according to a study published online March 1 in the Annals of the American Thoracic Society.

Takamitsu Asano, M.D., from the Nagoya City University Graduate School of Medical Sciences in Japan, and colleagues examined the utility of serum periostin as a diagnostic biomarker for upper airway disease in with . Sixty-five patients with stable asthma were enrolled: 20 without upper airway disease, 22 with rhinitis, and 23 with (13 with and 10 without nasal polyps). Serum periostin, eotaxin, total immunoglobulin E, fractional exhaled nitric oxide, and blood-sputum eosinophil levels were measured.

The researchers found that patients with asthma with chronic rhinosinusitis had higher serum periostin levels than those without upper airway disease (109.6 ± 47.4 ng/mL versus 83.2 ± 22.9 ng/mL; P = 0.04). Patients with asthma with chronic rhinosinusitis and nasal polyps had higher serum periostin levels than those without nasal polyps (130.0 ± 46.6 ng/mL versus 87.9 ± 37.7 ng/mL; P = 0.001). There was no correlation for serum periostin levels with the presence or severity of rhinitis. Receiver operating curve analyses showed moderate and high diagnostic accuracy for detecting chronic rhinosinusitis and chronic rhinosinusitis with nasal polyps, respectively (area under the curve, 0.71 and 0.86, respectively). Serum periostin was the only biomarker that detected the presence of nasal polyps when comparing patients with comorbid chronic rhinosinusitis and nasal polyps to those without.

"Serum periostin is useful for detecting chronic rhinosinusitis with and predicting radiological chronic rhinosinusitis severity in patients with asthma," the authors write.

The study was funded by research grants from pharmaceutical companies.

Explore further: Patients with severe chronic rhinosinusitis show improvement with Verapamil treatment

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Patients with severe chronic rhinosinusitis show improvement with Verapamil treatment

January 23, 2017
A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the ...

Markers that predict omalizumab response identified

May 2, 2016
(HealthDay)—Baseline serum periostin levels and levels of serum free immunoglobulin E (IgE) during treatment follow-up may be useful in assessing response to omalizumab treatment for asthma, according to a study published ...

Verapamil benefits chronic rhinosinusitis with nasal polyps

January 26, 2017
(HealthDay)—For patients with chronic rhinosinusitis with nasal polyps (CRSwNP), the first-generation inhibitor of epithelial P-glycoprotein (P-gp; an efflux pump that is overexpressed in CRSwNP), verapamil hydrochloride ...

Chronic rhinosinusitis linked to increased risk of other diseases

September 8, 2015
(HealthDay)—Chronic rhinosinusitis (CRS) is associated with increased risk of other diseases, with different patterns based on CRS phenotype, according to research published online Aug. 31 in Allergy.

Free light chains identified in chronic rhinosinusitis

July 16, 2012
(HealthDay) -- Patients with chronic rhinosinusitis (CRS) have increased free light chain (FLC) concentrations, particularly those with CRS with nasal polyps (CRSwNP), according to a study published online July 5 in Allergy.

Immune system blood cell a potential marker for sinus polyp regrowth

June 8, 2016
In an effort to identify a simple, reliable way to track the course of nasal polyps in chronic sinus disease, Johns Hopkins Medicine researchers say they've linked rising levels of immune system white blood cells, called ...

Recommended for you

'Icebreaker' protein opens genome for T cell development, researchers find

February 20, 2018
Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions. Determining what parts of the genome are read to make protein and ...

Preventive treatment for peanut allergies succeeds in study

February 20, 2018
The first treatment to help prevent serious allergic reactions to peanuts may be on the way. A company said Tuesday that its daily capsules of peanut powder helped children build tolerance in a major study.

Infection site affects how a virus spreads through the body

February 20, 2018
A person is more likely to get infected by HIV through anal intercourse than vaginal, but no one knows quite why. A new study by scientists at the Gladstone Institutes shows that infection sites could affect the immune system's ...

Unexpected immune activation illustrated in the cold

February 19, 2018
Researchers at Utrecht University and Leiden University Medical Center, the Netherlands, have imaged an important immune system on-switch. Their novel technical approach has led to the discovery of two ways in which the immune ...

Immune signature predicts asthma susceptibility

February 16, 2018
Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) ...

Scientists identify immune cascade that fuels complications, tissue damage in chlamydia infections

February 13, 2018
Closing a critical gap in knowledge, Harvard Medical School scientists have unraveled the immune cascade that fuels tissue damage and disease development in chlamydia infection—the most common sexually transmitted disease ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.