Exposure to BPA substitute, BPS, multiplies breast cancer cells

April 2, 2017
Micrograph showing a lymph node invaded by ductal breast carcinoma, with extension of the tumour beyond the lymph node. Credit: Nephron/Wikipedia

Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical, a new study finds. The results, which tested BPS in human breast cancer cells, will be presented Saturday at ENDO 2017, the Endocrine Society's 99th annual meeting in Orlando, Fla.

BPS is found in polycarbonate hard plastics, currency bills and thermal paper receipts as well as many products touted to be free of BPA, a known endocrine-disrupting chemical suspected of having multiple possible health risks.

"Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behavior to BPA," said the study's principal investigator, Sumi Dinda, Ph.D., associate professor at Oakland University School of Health Sciences, Rochester, Mich.

Their study confirmed that BPS acts like estrogen in , Dinda said, adding, "So far, BPS seems to be a potent endocrine disruptor."

He and his colleagues studied the effects of BPS on -alpha and the BRCA1 gene. Most breast cancers are estrogen receptor positive, and, according to the National Cancer Institute, 55 to 65 percent of women who inherit a harmful mutation in the BRCA1 gene will develop breast cancer.

Using two commercially available breast cancer cell lines obtained from women with estrogen-receptor-positive breast cancer, the research team exposed the cancer cells to varying strengths of BPS or to an inactive substance as a control.

The investigators also treated the breast cancer cells with estradiol (estrogen) and found that BPS acted like estrogen in multiplying breast cancer cells, Dinda said. Compared with the control, BPS heightened the protein expression in estrogen receptor and BRCA1 after 24 hours, as did estrogen. After a six-day treatment with BPS, the breast cancer cells in both cell lines reportedly increased in number by 12 percent at the lowest dose (4 micromolars) and by 60 percent at 8 micromolars.

The research team then blocked the BPS-induced proliferation of breast cancer cells by treating the cells with anti-estrogen drugs, which are used to block estrogen's action onto estrogen binding proteins (estrogen receptors) in breast cancer cells.

Dinda said their findings suggest that BPS may cause breast cancer to become more aggressive. Although further study of BPS in is needed for confirmation, he suggested that "if a woman has a mutated BRAC1 gene and uses products containing BPS, her risk for developing may increase further."

Co-author Katie Aleck, a research assistant at Oakland University, will present the study results at the meeting.

Explore further: Prevalence of estrogen receptor mutations in patients with metastatic breast cancer

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Azrael
5 / 5 (2) Apr 02, 2017
So ... these companies manufacturing plastic bottles and other items with BPA, after all the negative media coverage they received, simply replaced one endocrine disruptor with another, extremely similar endocrine disruptor, and proudly proclaim "BPA FREE!" on their product labels?

Where's the regulation? Is there any at all? Any testing? Any concern whatsoever for the public?

Doesn't seem like it.

Osiris1
not rated yet Apr 02, 2017
Bisphenol-S and Bisphenol-A or BPS and its discredited cousin BPA were more exactingly once called ' n-Sulfur bis-Phenol' and maybe 'n-Arsenic bis-Phenol' by its creators and its Internationa Union of Chemistry nomenclature for naming aromatic organic covalent compounds. As such they AND their use bear striking resemblance of sorts to Fentanyl and IT's multinefarious incarnations. Fentanyl, or the drug that killed Michael Jackson, was known by the medical pros and by cops long before it took Jackson. It was smuggled to the streets, promptly becoming an addictive and flexible recreational dope for junkies. Retired Los Angeles cop Joseph Wambaugh wrote of it in his books about crime in L.A. Seems as every time the California Assembly got to make it illegal, the crooks' chemists altered the molecule in some small way to 'make it legal again', just like BP...A morphed to BP-S. Problem could be bis-Phenol, period! No matter what the 'letter'!!
aksdad
not rated yet Apr 03, 2017
So maybe it's a bad idea to inject BPS and BPA into cancer cells. Or eat it.

So far no study has shown an increase in cancer caused by simply coming into contact with BPA or BPS, or drinking from BPA bottles. All the studies fed high doses of BPA to lab animals or put BPA / BPS directly in contact with cancer cells; something that would never happen in the real world...unless you have a taste for plastic and include it as a basic part of your diet or shoot up with it get to high on BPA. And an FDA study in 2014 concluded that rats fed low doses of BPA didn't have increased rates of cancer.

BPA is essentially harmless, used the way it is intended. Just don't eat a lot of it or inject it. As if you would.
qitana
not rated yet Apr 04, 2017
According to Wikipedia:

The CDC had found bisphenol A in the urine of 95% of adults sampled in 1988–1994[173] and in 93% of children and adults tested in 2003–04.[174] The USEPA Reference Dose (RfD) for BPA is 50 µg/kg/day which is not enforceable but is the recommended safe level of exposure. The most sensitive animal studies show effects at much lower doses,[93][108] and several studies of children, who tend to have the highest levels, have found levels over the EPA's suggested safe limit figure.[175]
qitana
not rated yet Apr 04, 2017
It leaks:

Bisphenol A is leached from the lining of food and beverage cans where it is used as an ingredient in the plastic used to protect the food from direct contact with the can.[168] It is especially likely to leach from plastics when they are cleaned with harsh detergents or when they contain acidic or high-temperature liquids.

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