Distinct maternal, fetal risks for anticoagulants in pregnancy

May 31, 2017

(HealthDay)—Anticoagulation for mechanical heart valves during pregnancy is associated with distinct maternal and fetal risks, according to a review published in the June 6 issue of the Journal of the American College of Cardiology.

Zachary L. Steinberg, M.D., from the University of Washington School of Medicine in Seattle, and colleagues compared the risk of adverse maternal and fetal outcomes in pregnant with valves receiving different methods of anticoagulation. Data were included for 800 pregnancies from 18 publications. The women were receiving either a vitamin K antagonist (VKA) throughout pregnancy; low-molecular weight heparin (LMWH) throughout pregnancy; LMWH for the first trimester followed by a VKA; or unfractionated heparin (UHA) for the first trimester followed by a VKA.

The researchers found that the composite maternal risk was lowest with VKA compared with LMWH, LMWH and VKA, or UFH and VKA (5 versus 16, 16, and 16 percent, respectively). The lowest composite fetal risk was seen with LMWH versus VKA, LMWH and VKA, or UFH and VKA (13 versus 39, 23, and 34 percent, respectively). Women taking ≤5 mg daily warfarin and those with an LMWH regimen had no significant difference in fetal risk.

"VKA treatment was associated with the lowest risk of adverse maternal outcomes, whereas the use of LMWH throughout was associated with the lowest risk of adverse fetal outcomes," the authors write.

One author disclosed financial ties to GlaxoSmithKline.

Explore further: Single-dose LMWH can interfere with algorithm for DVT diagnosis

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Single-dose LMWH can interfere with algorithm for DVT diagnosis

December 22, 2016
(HealthDay)—A single dose of low-molecular-weight heparin (LMWH) given the previous day can reduce D-dimer and potentially risk non-identification of a deep vein thrombosis (DVT), according to a research letter published ...

Post-op prophylactic heparin poses very low bleed risk

November 11, 2013
(HealthDay)—The risk of hemorrhage seems to be very low when prophylactic low-molecular-weight heparin (LMWH) is initiated 24 to 36 hours after degenerative spine surgery but the associated venous thromboembolism (VTE) ...

Review supports LMWH for cancer-linked incidental PE

October 29, 2015
(HealthDay)—Cancer-associated incidental pulmonary embolism (IPE) should be treated with low molecular weight heparins (LMWHs), according to a review published online Oct. 15 in the Journal of Thrombosis and Haemostasis.

After hip replacement, aspirin cost-effective for VTE prophylaxis

August 1, 2013
(HealthDay)—Aspirin is a cost-effective choice for prophylaxis of venous thromboembolism (VTE) following total hip arthroplasty, but the choice of aspirin versus low-molecular-weight heparin (LMWH) for patients younger ...

Pregnancy risks upped in women with intellectual disability

March 29, 2017
(HealthDay)—Pregnant women with intellectual and developmental disabilities are at increased risk for adverse maternal and offspring outcomes, according to a study published in the April issue of BJOG: An International ...

ACOG addresses thrombocytopenia in pregnancy

August 24, 2016
(HealthDay)—Thrombocytopenia is common in pregnancy and can have causes that are serious medical disorders, with potential for maternal and fetal morbidity, according to a Practice Bulletin published in the September issue ...

Recommended for you

Study finds women with pregnancy-related nausea, vomiting use marijuana more

August 20, 2018
A Kaiser Permanente study, published today in JAMA Internal Medicine, found that women with mild and severe nausea and vomiting in pregnancy were significantly more likely to have used marijuana during pregnancy than women ...

Blood test may identify gestational diabetes risk in first trimester

August 16, 2018
A blood test conducted as early as the 10th week of pregnancy may help identify women at risk for gestational diabetes, a pregnancy-related condition that poses potentially serious health risks for mothers and infants, according ...

Artificial placenta created in the laboratory

August 14, 2018
In order to better understand important biological membranes, it is necessary to explore new methods. Researchers at Vienna University of Technology (Vienna) have succeeded in creating an artificial placental barrier on a ...

The inequalities of prenatal stress

August 14, 2018
Exposure to an acute stress in utero can have long-term consequences extending into childhood – but only among children in poor households, according to a new Stanford study that looked at the long-term impact of acute, ...

Better studies needed on effectiveness of fertility awareness-based methods for contraception

August 10, 2018
A new systematic review provides the most comprehensive assessment to date on the scientific evidence estimating the effectiveness of various fertility awareness-based methods (FABMs) for contraception. "Effectiveness of ...

Inducing labor at 39 weeks reduces likelihood of C-sections

August 8, 2018
Inducing labor in healthy first-time mothers in the 39th week of pregnancy results in lower rates of cesarean sections compared with waiting for labor to begin naturally at full term, according to a multicenter study funded ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.