Distinct maternal, fetal risks for anticoagulants in pregnancy

May 31, 2017

(HealthDay)—Anticoagulation for mechanical heart valves during pregnancy is associated with distinct maternal and fetal risks, according to a review published in the June 6 issue of the Journal of the American College of Cardiology.

Zachary L. Steinberg, M.D., from the University of Washington School of Medicine in Seattle, and colleagues compared the risk of adverse maternal and fetal outcomes in pregnant with valves receiving different methods of anticoagulation. Data were included for 800 pregnancies from 18 publications. The women were receiving either a vitamin K antagonist (VKA) throughout pregnancy; low-molecular weight heparin (LMWH) throughout pregnancy; LMWH for the first trimester followed by a VKA; or unfractionated heparin (UHA) for the first trimester followed by a VKA.

The researchers found that the composite maternal risk was lowest with VKA compared with LMWH, LMWH and VKA, or UFH and VKA (5 versus 16, 16, and 16 percent, respectively). The lowest composite fetal risk was seen with LMWH versus VKA, LMWH and VKA, or UFH and VKA (13 versus 39, 23, and 34 percent, respectively). Women taking ≤5 mg daily warfarin and those with an LMWH regimen had no significant difference in fetal risk.

"VKA treatment was associated with the lowest risk of adverse maternal outcomes, whereas the use of LMWH throughout was associated with the lowest risk of adverse fetal outcomes," the authors write.

One author disclosed financial ties to GlaxoSmithKline.

Explore further: Single-dose LMWH can interfere with algorithm for DVT diagnosis

More information: Abstract/Full Text
Editorial (subscription or payment may be required)

Related Stories

Single-dose LMWH can interfere with algorithm for DVT diagnosis

December 22, 2016
(HealthDay)—A single dose of low-molecular-weight heparin (LMWH) given the previous day can reduce D-dimer and potentially risk non-identification of a deep vein thrombosis (DVT), according to a research letter published ...

Post-op prophylactic heparin poses very low bleed risk

November 11, 2013
(HealthDay)—The risk of hemorrhage seems to be very low when prophylactic low-molecular-weight heparin (LMWH) is initiated 24 to 36 hours after degenerative spine surgery but the associated venous thromboembolism (VTE) ...

Review supports LMWH for cancer-linked incidental PE

October 29, 2015
(HealthDay)—Cancer-associated incidental pulmonary embolism (IPE) should be treated with low molecular weight heparins (LMWHs), according to a review published online Oct. 15 in the Journal of Thrombosis and Haemostasis.

After hip replacement, aspirin cost-effective for VTE prophylaxis

August 1, 2013
(HealthDay)—Aspirin is a cost-effective choice for prophylaxis of venous thromboembolism (VTE) following total hip arthroplasty, but the choice of aspirin versus low-molecular-weight heparin (LMWH) for patients younger ...

Pregnancy risks upped in women with intellectual disability

March 29, 2017
(HealthDay)—Pregnant women with intellectual and developmental disabilities are at increased risk for adverse maternal and offspring outcomes, according to a study published in the April issue of BJOG: An International ...

ACOG addresses thrombocytopenia in pregnancy

August 24, 2016
(HealthDay)—Thrombocytopenia is common in pregnancy and can have causes that are serious medical disorders, with potential for maternal and fetal morbidity, according to a Practice Bulletin published in the September issue ...

Recommended for you

Air pollutants linked to abnormal fetal growth

February 23, 2018
Chinese mothers who were exposed to a high level of certain air pollutants during pregnancy had a higher risk of abnormal fetal growth, according to a new Yale School of Public Health (YSPH) study.

Scientists discover critical molecular biomarkers of preeclampsia

February 21, 2018
Preeclampsia, a sudden pregnancy complication that can interfere with the blood flow to the placenta and possibly to the fetus, can lead to low birth weight, prematurity and even death. It is also a leading cause of maternal ...

Transgender women can breastfeed, first case study shows

February 16, 2018
The first scientific case study has been published describing how a US transgender woman was able to breastfeed her adopted infant by taking hormones that induce lactation.

Controversial pregnancy test drug shows deformities in zebrafish embryos within hours of exposure

February 13, 2018
The components of a controversial drug, allegedly linked to birth defects in the 1960s and '70s, caused deformations to fish embryos just hours after they received a dose in new studies by researchers at the University of ...

Direct link between glands and implanting embryos critical to pregnancy

February 9, 2018
Researchers used 3D imaging with molecular testing to uncover new insight into the earliest stages of mammalian pregnancy—offering clues to unsolved questions in pregnancy.

Lab-grown eggs could pave way towards new fertility treatments

February 8, 2018
Human eggs have been fully grown in a laboratory, in a move that could lead to improved fertility treatments.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.