Low-dose aspirin no aid against cognitive decline
Nicola Veronese, M.D., from the Italian Research Council in Padova, and colleagues conducted a systematic literature review to identify observational and interventional studies that investigated low-dose aspirin and the incidence of dementia and cognitive impairment.
The researchers identified eight studies (36,196 participants). Over a median of six years of follow-up, chronic use of low-dose aspirin was not associated with onset of dementia or cognitive impairment (five studies; 26,159 participants; odds ratio, 0.82; 95 percent confidence interval, 0.55 to 1.22; P = 0.33), after adjusting for a median of three potential confounders. In three randomized controlled trials (10,037 participants; median follow-up, five years), the use of low-dose aspirin in individuals without dementia was not associated with significantly better global cognition (standardized mean difference, 0.005; 95 percent confidence interval, −0.04 to 0.05; P = 0.84).
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