Lung therapy hope for critical illness

May 8, 2017, University of Edinburgh

Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition.

The discovery could eventually lead to new therapies for the disease, which can be fatal for up to half of those affected.

Inflammation

Acute Respiratory Distress Syndrome (ARDS) is caused by widespread inflammation in the lungs and can lead to fluid leaking into the airways.

Researchers found that patients with ARDS had high levels of a type of molecule called mitochondrial formylated peptide in the fluid of their lungs.

Laboratory tests found that these molecules play a key role in attracting specialised called neutrophils.

Neutrophils are known to be responsible for orchestrating the inflammation associated with ARDS.

Studies with mice found that blocking the molecules' signalling mechanisms helped to stem neutrophil infiltration and alleviate lung inflammation associated with ARDS.

Experts at the University of Edinburgh say the findings could pave the way for new therapies for the condition, which is untreatable.

"For the first time, we have demonstrated that these mitochondrial formylated peptides are present and elevated in ARDS and that they directly drive . This therefore highlights a potential novel therapeutic target for this life threatening illness," says Professor Adriano Rossi.

Critical illness

ARDS typically affects patients who are already critically ill and can be triggered by severe injuries or infections such as pneumonia.

Mitochondrial formylated peptides are released from the body's cells when they die. Therapies that target these molecules could potentially help patients with any type of ARDS, whether caused by an infection or not, the researchers say.

The study is published in the journal Thorax.

Explore further: Immune cell insight offers hope for tackling deadly lung condition

More information: David A Dorward et al, Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome, Thorax (2017). DOI: 10.1136/thoraxjnl-2017-210030

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