Nomogram predicts survival for adults undergoing CAC scoring

June 15, 2017

(HealthDay)—A simple-to-use nomogram can predict five-, 10-, and 15-year survival among adults undergoing coronary artery calcium scoring (CACS), according to a study published online June 14 in JACC: Cardiovascular Imaging.

Bríain Ó Hartaigh, Ph.D., from the Dalio Institute of Cardiovascular Imaging in New York City, and colleagues developed and validated a simple-to-use nomogram for prediction of survival among asymptomatic adults undergoing CACS. The nomogram was developed in 9,715 individuals undergoing CACS and included age, sex, smoking, hypertension, dyslipidemia, diabetes, family history of disease, and CACS. A prognostic index (PI) was developed, summing the number of risk points corresponding to weighted covariates. The nomogram was validated in a separate cohort of 7,824 adults undergoing CACS.

The researchers found that during median follow-up of 14.6 and 9.4 years, there were 936 and 294 deaths in the derivation and validation sets, respectively. The model effectively predicted the probability of five-, 10-, and 15-year survival. In the derivation and validation sets, the PI displayed high discrimination (C-index, 0.74 and 0.76, respectively). In each dataset, the predicted and actual estimates of survival according to PI quartiles were similar.

"A simple-to-use nomogram effectively predicts five-, 10- and 15-year survival for asymptomatic adults undergoing screening for cardiac risk factors," the authors write. "This nomogram may be considered for use in clinical care."

One author disclosed financial ties to the biopharmaceutical and health care industries.

Explore further: Nomogram predicts death, recurrence with thyroid cancer

More information: Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Nomogram predicts death, recurrence with thyroid cancer

October 1, 2015
(HealthDay)—A new nomogram has excellent discriminatory ability and accuracy in predicting 10-year disease-specific death and recurrence for papillary thyroid carcinoma (PTC), according to a study published online Sept. ...

Nomogram developed to estimate early breast cancer survival

June 27, 2012
(HealthDay) -- A nomogram has been developed to predict five- and 10-year mastectomy-free survival (MFS) in older women with early breast cancer and estimate the predicted benefit of radiation therapy (RT) following conservative ...

Statistical tool predicts risk of major postop complications

October 16, 2015
(HealthDay)—A statistical tool can accurately estimate an individual patient's risk of developing a major complication after surgery for oral cavity squamous cell carcinoma, according to a study published online Oct. 15 ...

MRI measures can predict pulmonary arterial HTN outcome

April 3, 2017
(HealthDay)—Magnetic resonance imaging (MRI) measures can predict outcomes in pulmonary arterial hypertension (PAH), according to a study published online March 22 in the American Journal of Respiratory and Critical Care ...

New prognostic factors may be useful in staging melanoma

July 16, 2014
(HealthDay)—New prognostic factors may be useful in predicting survival in patients with thin melanoma, according to research published online July 7 in the Journal of Clinical Oncology.

Recommended for you

How genes and environment interact to raise risk of congenital heart defects

October 19, 2017
Infants of mothers with diabetes have a three- to five-fold increased risk of congenital heart defects. Such developmental defects are likely caused by a combination of genetic and environmental factors. However, the molecular ...

Mouse studies shed light on how protein controls heart failure

October 18, 2017
A new study on two specially bred strains of mice has illuminated how abnormal addition of the chemical phosphate to a specific heart muscle protein may sabotage the way the protein behaves in a cell, and may damage the way ...

Newborns with trisomy 13 or 18 benefit from heart surgery, study finds

October 18, 2017
Heart surgery significantly decreases in-hospital mortality among infants with either of two genetic disorders that cause severe physical and intellectual disabilities, according to a new study by a researcher at the Stanford ...

Saving hearts after heart attacks: Overexpression of a gene enhances repair of dead muscle

October 17, 2017
University of Alabama at Birmingham biomedical engineers report a significant advance in efforts to repair a damaged heart after a heart attack, using grafted heart-muscle cells to create a repair patch. The key was overexpressing ...

Physically active white men at high risk for plaque buildup in arteries

October 17, 2017
White men who exercise at high levels are 86 percent more likely than people who exercise at low levels to experience a buildup of plaque in the heart arteries by middle age, a new study suggests.

High blood pressure linked to common heart valve disorder

October 17, 2017
For the first time, a strong link has been established between high blood pressure and the most common heart valve disorder in high-income countries, by new research from The George Institute for Global Health at the University ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.