BASF introduces first new class of public health insecticide for malaria prevention in more than 30 years

BASF unveils new class of insecticide for malaria prevention
There are more than 200 million cases of malaria each year and almost half a million deaths mostly among children under five. Now more than 60 countries have reported resistance to currently used interventions. Interceptor G2 from BASF is the first WHO-recommended mosquito net to bring a new class of insecticide to the public health sector and help beat insecticide-resistant mosquitoes. Credit: Lassen/BASF

BASF has received a recommendation from the World Health Organization (WHO) for Interceptor(R) G2, a long-lasting insecticide-treated mosquito net (LN) based on chlorfenapyr. Chlorfenapyr is a completely new insecticide class for combating mosquitoes for public health. This is the first WHO recommendation for a product based on a new insecticide class in more than 30 years.

Working with the Innovative Vector Control Consortium (IVCC) and the London School of Hygiene & Tropical Medicine in a collaboration lasting over a decade, BASF's scientists successfully repurposed chlorfenapyr to be effective on mosquito nets and meet stringent WHO performance thresholds for public .

Dave Malone, IVCC Technical Manager, said "The collaboration with BASF gave us access to an with a rare combination of attributes: New to public health, effective against resistant , and able to coat polyester netting with a long-lasting formulation."

A second chlorfenapyr product, an indoor residual spray named Sylando(R) 240SC, is also in the final phases of WHO evaluation.

Around the world, every two minutes a child dies from malaria and there are more than 200 million new cases every year. Malaria is also a major cause of global poverty and its burden is greatest among the most vulnerable.

Long-lasting insecticide-treated mosquito nets (LN) and indoor residual sprays are the cornerstones of malaria prevention, particularly in sub-Saharan Africa. But 60 countries have already reported resistance to at least one class of insecticide used in them. Part of the problem is that there were previously only four WHO-recommended insecticide classes for adult mosquito control: Only one of them, the pyrethroid class, was recommended for LNs. Continual use of the same insecticides enabled the highly-adaptable mosquito to develop significant levels of resistance.

The scientists and developers behind Interceptor G2 talk about the new product and what this breakthrough means for malaria control. Credit: BASF

Independent trials in Benin, Burkina Faso, Tanzania and Ivory Coast have proven the efficacy of Interceptor G2 and Sylando 240SC against local insecticide-resistant mosquitoes.

Medical entomologist Professor Hilary Ranson from the Liverpool School of Tropical Medicine has studied the problem for many years. "We've got to take very seriously," she said. "In some countries, the local mosquito population has increased its level of resistance 1,000-fold. It has been years since a new class of public health insecticide has appeared on the market. Alternatives are urgently needed."

Following the WHO recommendation, BASF will start preparations to launch Interceptor G2 for . Depending on local registration processes, the new mosquito net is expected to be available to health ministries and aid organizations starting towards the end of this year.

"New resistance management products are desperately needed to prevent mosquito-borne diseases and save lives," said Egon Weinmueller, Head of BASF's business. "This development breakthrough strengthens my personal belief that we really can be the generation to end malaria for good."

BASF unveils new class of insecticide for malaria prevention
Interceptor G2 from BASF is the first WHO-recommended mosquito net based on non-pyrethroid chemistry to beat insecticide-resistant mosquitoes. Its distinctive black and white stripes distinguish it from currently used mosquito nets. Volker Frenz, development chemist for the innovative new net checks samples in the laboratory. Credit: Andres/BASF

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Insecticide-treated nets may still prevent malaria despite mosquito resistance

More information: Koama Bayili et al, Evaluation of efficacy of Interceptor® G2, a long-lasting insecticide net coated with a mixture of chlorfenapyr and alpha-cypermethrin, against pyrethroid resistant Anopheles gambiae s.l. in Burkina Faso, Malaria Journal (2017). DOI: 10.1186/s12936-017-1846-4
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Citation: BASF introduces first new class of public health insecticide for malaria prevention in more than 30 years (2017, July 13) retrieved 18 January 2019 from https://medicalxpress.com/news/2017-07-basf-class-health-insecticide-malaria.html
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