Brexanolone tolerated in super-refractory status epilepticus

Brexanolone tolerated in super-refractory status epilepticus

(HealthDay)—For patients with super-refractory status epilepticus (SRSE), brexanolone as adjunctive therapy is tolerated and associated with a high rate of third-line agent (TLA) weaning, according to a study published online Aug. 5 in the Annals of Neurology.

Eric S. Rosenthal, M.D., from Massachusetts General Hospital in Boston, and colleagues conducted a multi-center study involving 25 SRSE patients to examine the safety and tolerability of brexanolone. Patients receiving TLAs for SRSE control were eligible for brexanolone loading infusions followed by maintenance infusion. TLAs were weaned during brexanolone maintenance after 48 hours of infusion. Brexanolone dose was tapered after four days.

The researchers noted no serious adverse events (SAEs) attributed to the study drug. Overall, 16 patients experienced one or more SAEs. There were six deaths, which were all related to underlying medical conditions. Twenty-two patients underwent one or more attempts at TLA weaning. The response end point of weaning successfully off TLAs before tapering brexanolone was met by 17 patients (77 percent). Within five days of initiating brexanolone , 16 were successfully weaned off TLAs without anesthetic agent reinstatement in the following 24 hours.

"The results suggest the possible development of brexanolone as an adjunctive therapy for SRSE requiring pharmacologic coma for seizure control," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Sage Therapeutics, which manufactures brexanolone and funded the study.

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Citation: Brexanolone tolerated in super-refractory status epilepticus (2017, August 9) retrieved 5 April 2020 from
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